...Hutchinson- Gilford Progeria syndrome(HGPS) which is more commonly known as Progeria is an extremely rare genetic disorder in which the child ages rapidly. Progeria must be diagnosed and is a lifelong illness. Progeria was first detected by Dr. Jonathan Hutchinson in 1886, then by Dr. Hastings Gilford in 1897. This is evidently where the disorder got its name. Progeria is caused by a genetic mutation that occurs before birth. The mutation occurs in the LMNA gene. The LMNA gene is responsible for creating a protein that helps maintain the structure of the nucleus in a cell. The LMNA gene holds the nucleus together, and without strength in the nucleus, the cells can become weak and cause aging. HGPS is a sporadic autosomal dominant mutation....
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...71197421 progeria-hutchison-gilford syndrome 3 Pages, 5 Sources, APA Style Preferred language style: English (U.S.); This topic is based on a topic of biotechnology, I have chosen progeria-hutchison-gilford syndrome. This paper needs to include an intro, body, conclusion, description of topic, demonstration of understanding, relation to health/nursing, accuracy and evidence of research. Progeria Hutchinson Gilford Syndrome (HGP syndrome) is a genetic condition that is fatal and is characterized by the child developing features of premature ageing. It tends to affect the musculoskeletal system, skin and the blood vessels. The disorder was reported separately by two different persons namely Hutchinson and Gilford in the late part of the 19th century. Till today about 100 cases of the disorder have been reported. About one in every 8 million births may develop this disorder. Many cases may go unrecognized, undiagnosed, or associated with stillborn children. The mortality rate of the condition is high due to heart and vascular disorders. A Child affected with the disorder may live for about 10 to 12 years. The condition more often affects males compared to females in the ratio of 5: 1. During the infancy stage, the child may appear to be normal, but after the age of 9 months to 24 months, the child begins to experience features of growth delays, stunted growth, short stature and the failure to put on body weight. The exact mechanism by which the disorder develops...
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...Progeria Progeria is a rare genetic disease that causes children to age faster than usual. According to an article by Christian Nordqvist, “The condition is extremely rare, affecting around 1 in every 4 million children”. Signs of progeria are not noticed until the age around two. Progeria, also known as Hutchinson-Gilford progeria syndrome, is caused by a gene mutation. “Most children with progeria have a mutation on the gene that encodes for lamin A, a protein that holds the nucleus of the cell together” (Nordqvist). The defective protein makes the nucleus unstable, making the cell more likely to die younger. This creates indications of progeria. Even though a parent does not have progeria, the mutation may still be present. Genetic testing can indicate if...
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