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L-Copa Research Paper

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Parkinson’s disease is associated with a lack of dopamine in the brain. It affects thousands of people, generally the older population, causing tremors and muscle rigidity (Yahr). Currently, there is no cure and people turn to medication, deep brain stimulation, or fetal brain implants. Every patient is different and reacts differently to the array of treatments. The problem with dopamine is that it cannot simply be injected into the person to serve as a cure because it cannot cross the blood brain barrier. Fortunately, scientists discovered L-DOPA, which is a precursor to dopamine and can cross the blood brain barrier. However, L-DOPA cannot be used for the long term because eventually the person develops a tolerance. Once a tolerance develops, the cons start to outweigh the benefits and the treatment stops. Deep brain stimulation is something scientists do not fully understand, but has proved successful in suppressing symptoms. This treatment uses a pacemaker-like device that is connected to an electrode implanted in the brain (Yahr). I support deep brain stimulation because it is a great …show more content…
This leads to the problem of unknown risk to benefit level since several long-term risks are unknown. The 2005 study published by M.C Rodriguez-Oroz looked at 69 patients with Parkinson’s disease over 4 years to observe the benefits. Depending on the patient, they underwent deep brain stimulation on parts of the basal ganglia, either the globus pallidus or subthalamic nucleus (Rodriquez). In conclusion, PD patients had a significant decrease in symptoms for at least 4 years based on this bilateral DBS treatment (Rodriquez). This conclusion aligned with the recent findings of the Grenoble group who followed up with patients after 5 years under the treatment and found them to still exhibit anti-parkinsonian effects

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