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Left Ventricular Pressure

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The aortic valve is a semilunar valve in that heart that guards the opening of the left ventricle (LV) into the aorta. It allows blood to flow into the aorta during left ventricular systole via opening, when the left ventricular pressure exceeds the arterial pressure in the aorta. Likewise, it prevents the backflow of blood during left ventricular diastole via closing, when the arterial pressure exceeds the left ventricular pressure.1
Aortic stenosis (AS) is the turbulent flow of blood into the aorta due to the pathological narrowing of the aortic valve’s orifice, resulting in a systolic murmur.3 AS can lead to “diastolic and systolic derangement of ventricular function with a resultant decline in ejection fraction, transvalvular flow, and …show more content…
Rheumatic aortic stenosis is caused by rheumatic fever; it involves …show more content…
As the orifice of the aortic valve is progressively narrowed in AS, the stroke volume (SV) and CO is restricted. This often manifests as exertional fatigue. During exercise, as blood flow increases, the aortic jet velocity and pressure gradient between the left ventricle and aorta increases, resulting in blunted or hypotensive blood pressure. Moreover, severe AS can lead to left ventricular hypertrophy and hindered left ventricle compliance and filling. As there is fixed obstruction to LV outflow, the LV experiences chronic pressure overload. This is compensated for by left ventricular hypertrophy (LVH), wherein there is parallel replication of the sarcomere, increasing the wall thickness of the LV, whilst maintaining regular LV diastolic dimensions. This mechanism retains LV contractility by normalising wall stress. However, progressive LVH results in impeded LV compliance, and thus, diastolic dysfunction, which leads to increased mean left atrial pressures. As AS progresses, the increased wall thickness may become inadequate in offsetting the increase in pressure with afterload mismatch, leading to increased wall stress, and decreased LV systolic function. Such reduction in LV systolic function also results in increased mean left atrial pressure, which with time, induces left atrial dilation, which may lead to atrial arrhythmias. Furthermore, hindered filling restricts LV preload at rest and

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