Free Essay

Odontogenic Tumours

In: Other Topics

Submitted By skeenybabe
Words 1348
Pages 6
Odontogenic Tumours

Odontogenic tumours are generally considered rare in all species. However, precise epidemiological data are not available for the dog and cat. One of the main reasons for this is the continuing confusion regarding the true nature of some of these lesions. In many surveys the so-called epulides, which are localized swellings on the gingival margin and which constitute a variety of pathological entities, are either grouped together or excluded. Recent findings indicate that many epulides are odontogenic tumours. Another reason is the fact that many clinicians do not routinely submit epulides for histopathological examination, thereby introducing bias in the studies based on archival material. An accurate assessment of the nature of the condition is a prerequisite for therapeutic decision-making. It is therefore important to understand the biology of odontogenic tumours.
Odontogenic tumours have traditionally been classified based on the presence or absence of the phenomenon of induction. To understand the classification based on induction, it is important to consider the reciprocal interactions of epithelial and mesenchymal tissues during odontogenesis. The epithelial dental lamina invaginates to form the enamel organ. The inner enamel organ epithelium consists of the pre-ameloblasts. The mesenchymal odontoblast precursors migrate to the basement membrane and eventually make contact with the pre-ameloblasts. The pre-ameloblasts then induce the odontoblasts to form the dentin. In turn, the odontoblasts influence the ameloblasts and these cells start secreting the enamel matrix. The mesenchymal stroma enclosed in the developing dental follicle is induced to take on the characteristics of dental pulp. As tooth formation is completed, the odontogenic epithelium disappears leaving behind the epithelial rests of Malassez in the periodontal ligament. These clusters of epithelial cells retain their odontogenic potential, which may subsequently be expressed in neoplasia.
The ameloblastoma is an example of a non-inductive tumour. In this tumour-type, the neoplastic cells of ameloblast origin do not induce the surrounding mesenchymal cells. Therefore, no dental hard tissues are formed and the tumour remains essentially a soft-tissue tumour. The odontoma is the best example of an inductive tumour. Odontomas are tumours of odontogenic epithelium with induction of odontogenic ectomesenchyme, characterized by the formation of all dental hard and soft tissues, including enamel, dentin, cementum, and pulp. Although the classification based on induction has recently been abandoned, there is merit in this classification as understanding the underlying processes helps to understand the clinicopathological correlations.
The World Health Organization has recently adopted a classification based on the epithelial, mesenchymal or mixed epithelial-mesenchymal origin of the neoplastic cells, rather than one based on inductive changes. The following table summarizes the currently accepted classification of odontogenic tumours in man, with one example of each type known to occur in animals:

Tumours Related to the Odontogenic Apparatus | Benign | Malignant | Odontogenic epithelium without odontogenic ectomesenchyme | Odontogenic epithelium with odontogenic ectomesenchyme, with or without dental hard tissue formation | Odontogenic ectomesenchyme with or without included odontogenic epithelium | Odontogenic carcinomas | Odontogenic sarcomas | Odontogenic carcinosarcoma | e.g., ameloblastoma | e.g., odontoma | e.g., odontogenic fibroma | e.g., primary intra-osseous carcinoma | e.g., ameloblastic fibrodentinosarcoma | |
The (central or intra-osseous) ameloblastoma is one of the most common odontogenic tumours (occasionally incorrectly referred to as an adamantinoma). This tumour usually presents as a locally invasive neoplasm with osteolysis around the tooth roots and cystic changes. The classic histological appearance of an ameloblastoma is a follicular arrangement of ameloblasts and stellate reticulum cells, resembling the basic structure of the enamel organ. A number of histological variants are known to occur. Ameloblastoma in the dog is often characterized by focal keratinization. Metastasis has not been described.
The canine acanthomatous or peripheral ameloblastoma is a benign odontogenic tumour with the same histological characteristics as the centrally located ameloblastoma, but appearing in the gingiva and mucosa of the tooth-bearing area of the jaws. In one review of canine epulides, the majority of lesions, which were originally classified as acanthomatous epulis, were found to be peripheral ameloblastoma. These lesions are composed of islands and sheets of mature squamous epithelium within a collagenous fibrous connective tissue stroma of low to moderate cellularity. These islands and sheets are each bounded by a row of palisading cells with nuclear polarization away from the basement membrane. Infiltration in the underlying bone is evident in most cases. The radiological picture of peripheral ameloblastoma is dominated by discrete infiltration, alveolar bone resorption, and tooth displacement. Although histologically very similar, this variant of ameloblastoma differs from the peripheral ameloblastoma in man in that it invades bone. The term canine acanthomatous ameloblastoma was therefore suggested to make this distinction. In the dog, local recurrence is very common following marginal excision and wide or radical excision is therefore recommended.
A large proportion of tumours previously described as fibromatous and ossifying epulides are peripheral odontogenic fibromas. This is a slow-growing, benign neoplasm characterized by the proliferation of fibrous tissue in which isolated islands or strands of odontogenic epithelium are present. A variety of bone, osteoid, dentinoid, or even cementum-like material may be found, often in close association with the odontogenic epithelium, suggesting mesenchymal induction. Radiological features vary according to the presence and amount of mineralized products. Peripheral odontogenic fibroma does not recur if adequately excised. In man, the peripheral odontogenic fibroma is a rare condition, whereas it is common in the dog.
An odontoma is a tumour in which both the epithelial and mesenchymal cells are well differentiated resulting in the formation of all dental tissue types. An odontoma may also be considered a hamartoma rather than a neoplasm. The dental tissues may or may not exhibit a normal relation to one another. An odontoma in which tooth-like structures are present, indicates advanced cellular differentiation and is referred to as a compound odontoma. On the other hand, an odontoma in which the conglomerate of dental tissues bears no resemblance to a tooth is called a complex odontoma. Odontomas have been diagnosed in young dogs and in the cat. The radiological appearance is typical and is either a sharply defined mass of calcified material surrounded by a narrow radiolucent band or a variable number of tooth-like structures. An odontoma may be associated with unerupted teeth, a dentigerous cyst, or may be attached to an otherwise normal tooth. The term ameloblastic odontoma is occasionally encountered in the veterinary literature. An ameloblastic odontoma is an ameloblastoma with focal differentiation into an odontoma. fELINE INDUCTIVE ODONTOGENIC TUMOUR
This tumour type was originally described in young cats as inductive fibro-ameloblastoma. Ameloblastic epithelial cells arranged around dental pulp-like stroma characterize this tumour. The rostral maxilla is the most common site of occurrence. The tumour may be locally invasive, but metastasis has not been recorded.
This tumour type is rare and may also present clinically as an epulis. It has been referred to in the veterinary literature as a calcifying epithelial odontogenic tumour, although it was found that it is not the canine counterpart of the human CEOT. The term, amyloid-producing odontogenic tumour, would therefore seem more appropriate for this lesion. The tumour bears some resemblance to an ameloblastoma: the epithelium in some areas exhibits palisading of the basal cells and stellate reticulum may occur focally. The most prominent feature is the presence of amyloid that tends to calcify. Recurrence after excision has been reported, but metastasis does not take place.
1. Gardner DG. Epulides in the dog: a review. J Oral Pathol Med 1996; 25(1):32-37.
2. Gardner DG, Dubielzig RR. Feline inductive odontogenic tumor (inductive fibroameloblastoma)—a tumor unique to cats. J Oral Pathol Med 1995;24(4):185-190.
3. Gardner DG, Dubielzig RR, McGee EV. The so-called calcifying epithelial odontogenic tumour in dogs and cats (amyloid-producing odontogenic tumour). J Comp Pathol. 1994;111(3):221-230.
4. Kramer IRH, Pindborg JJ, Shear M. Histological Typing of Odontogenic Tumours. 2nd ed. Springer Verlag, Berlin, 1992.
5. Verstraete FJM, Ligthelm AJ, Weber A. The histological nature of epulides in dogs. J Comp Pathol 1992;106(2):169-182.

Similar Documents

Free Essay

Tasmanian Devil

...Taz and Ant; One Endangered, One Invasive Taylor Drake Biology 106A, Fall 2012 In a world dominated by humans there are many things that also inhabit Earth, one of those being animals. Sometimes these animals can thrive in certain or multiple geographical areas while others, due to humans, may fail to adapt and survive. An invasive species is one that has a native geographical range but then somehow gets transferred to a new geographical range where it possibly can thrive and cause problems such as the Red Imported Fire Ant. On the other hand, there are some species of animals that are endangered and on the brink of extinction like the Tasmanian devil. With the encroachment of humans on the animal’s environment, they have hindered their ability to thrive forcing them to become endangered. Humans influence on the ecosystem, animals have to adapt like the Red Fire Ant or be forced to near or possible extinction like the Tasmanian devil. 1 The Tasmanian devil (Figure 1), Sarcophilus harrisii, is the largest carnivorous marsupial of the family Dasyuridae found on the Australian island of Tasmania (Figure 2) (Tasmanian devil). The devil is normally black with a white patch around its neck and generally about the size of a small dog weighing between fifteen and twenty Figure 1. The Tasmanian devil, Sarcophilus harrisii pounds (Tasmanian Devil). On Tasmania, it lives in coastal scrubs and eucalypt forests but is also found near places of human inhabitance because......

Words: 1930 - Pages: 8

Free Essay

Endangered Spiecies-Tasmainian Devil

...DETAILED DESCRIPTION HABITAT The unique Tasmanian devils were once abundant throughout Australia. They are now isolated in Tasmania only, hence their given name, the Tasmanian devil. Fossils found in Western Australia dated back to 2000 years but the precise explanation as to the disappearance of them inhabiting the mainland is suggested to be the introduction of the dingo. (National Geographic’s-Tasmanian Devil) The small and vulnerable size of the Tasmanian devil perhaps predicts his habitat of forests and dens foliage giving him ample coverage and protection. During the day the devil is hidden away in dens, caves or hollow logs. TASMANIAN DEVIL GEOGRAPHY ASSIGNMENT YEAR 8 SIENNA OTTO 2014 PHYSICAL DESCRIPTION These creatures might only be the size of small dog (up to 75 centimetres) but they have a life saving feature and that’s their all mighty tenacious jaw. The devils huge head holds the most powerful, bone crushing jaws on earth. The force comes from an impressive upper body design of a head disproportionally larger than the rest of its torso. Their powerful mouth compensates for their vulnerable small body size. However, the structure of the devils legs shows them having long front legs but shorter rear legs giving them the ability to reach up to speeds of 25 kilometre an hour (Parks and Wildlife Service- Tasmanian devil- Frequently Asked Questions). Its course, thin, black fur along with its stocky build resembles ones of a baby bear and they......

Words: 1413 - Pages: 6