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Osteoblast Research Paper

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Bone is continuously reabsorbed and replaced through a constant remodeling process to maintain bone density, skeletal strength and integrity, with 10% of the skeleton being replaced annually. The osteoclast are the main bone resorbing cell derived from Hematopoietic stem cells (HSCs) from the peripheral blood and bone marrow, they lay on the bone and release catalytic enzymes and HCl to dissolve bone (which cause the release of growth factors and calcium). After bone resorption from osteoclast, mesenchymal stem cells (MSCs)-derived osteoblast replace the voids with new bone, a process characterized by osteoblast commitment, proliferation and differentiation which is later couple with osteoblast production of type I collagen and its subsequent

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