...Running head: GAP ANALYSIS: INTERSECT INVESTMENTS Gap Analysis: Gene One Stacy Starkes University of Phoenix May 17, 2010 Gap Analysis: Intersect Investments Gene One is a ground-breaking Biotech organization that has been faced with many issues. The organization has been forced to expand at a rapid rate to meet the organizational goals of becoming one of the leading organizations in the biotech industry. In order to compete with the ever increasing biotech industry, the CEO and the board of directors believe that going public within the next three years would be beneficial for the organization. By making the appropriate choices of becoming a publically traded organization, Gene One will bark upon a journey that will help them to revolutionize and to use cutting edge technology of eliminating pesticides on tomatoes and potatoes to meet the organizational goals. The rapid growth rate took the organization from a small $2 million start-up company to more than a $400 million in annual sales. Therefore, by implementing an IPO strategy and implementing other strategic goals will help fulfill the organizations growth target and prove the organization is worthy of its capabilities. In addition, the method of benchmarking can help Gene One to succeed and enable the organization to find the necessary solutions to the most pressing and immediate issues. According to The Benchmarking Exchange (2010), “Benchmarking is the process of measuring an organization's internal processes...
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...Nature versus Nurture Psychology 101 The flight test director for Boeing and a drug addict living in a trailer have more in common than you might think; in this case they are siblings. The brothers are born from the same parents, raised in the same home, given the same opportunities, yet polar opposites of one another. Scenarios such as this pose the question of what makes a person who they are, their environment, or their genes. For centuries the controversy between nature and nurture has been argued among experts. The debate is whether environmental influences or genetic inheritance is responsible for our human makeup. History of Nature versus Nurture From the thirteenth century researcher to present day, the nature nurture controversy is anything but a new topic, although techniques and biases may differ throughout the centuries. In the Beginning In 1874, Francis Galton, published his book English Men of Science: Their Nature and Nurture, which “lays partial claim to the nature versus nurture phrase” (Groff, 1998, para.1). Galton states nature and nurture, “separates under two distinct heads the innumerable elements of which personality is composed. Nature is all that a man brings with him into the world; nurture is every influence from without that affects him after his birth” (Galton, 1874). However, in 1911 a manuscript was found dating back to the thirteenth century which suggested the terms of nature and nurture as well. Previous to this, the philosophers...
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...Houston, TX 77030; email mlfrazier@notes .mdacc.tmc.edu. INTRODUCTION IT IS POSSIBLE TO test selected subjects for germline mutations in genes causing familial adenomatous polyposis (FAP),1 hereditary nonpolyposis colorectal cancer(HNPCC),2-8 Peutz-Jeghers syndrome,9,10 and juvenile polyposis.11-13 Because the genes that are mutated in familial colorectal cancer syndromes can be mutated at a variety of different locations, assays for mutation detection are not simple. Many different approaches to mutation detection have been described in the literature, some of which are also described here. Specific strategies for testing are also discussed. THE BASICS Isolation of DNA and Polymerase Chain Reaction (PCR) DNA or RNA for genetic testing is almost always isolated from peripheral-blood leukocytes. This requires that the blood be drawn in tubes containing some sort of anticoagulant. The preferred anticoagulants are either citrate or EDTA. The cells are lysed followed by removal of the other cellular components and precipitation of the DNA or RNA in ethanol. One of the drawbacks of this approach is that the blood must be rapidly transported to the laboratory where the testing will be performed before the nucleic acids begin to degrade. Recent developments in filter paper technology show promise in obviating this problem. Special filter papers...
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...controlled by one gene with two alleles, where T is dominant to t. INTRODUCTION Mendel’s Law of Segregation – that two copies of a character (gene) segregate from each other during the formation of gametes, is apparent in the inheritance of PTC tasting in humans (Begg, 1959). The PTC sensory variation was first discovered in the early 1930s by A.L. Fox, which subsequently led to much research. It was reported not long after that PTC tasting is controlled by one gene with two alleles, and that inheritance of these traits is that of Mendel’s monohybrid ration of 3:1. However, there is evidence to suggest transmission of PTC tasting is more complex than this (Kim & Drayna, 2005). The presence of the dominant allele T determines wether or not an individual can taste PTC. A monohybrid cross of two heterozygotes results in three possible genotypes – TT, Tt, and tt, the only non-taster phenotype being tt (Schull, 1948). This study investigated inheritance of PTC tasting in humans to determine wether or not taster and non-taster phenotypes fell into the expected Mendelian ration. It was hypothesised that there would be a ratio of 3 taster: 1 non-taster phenotypes, and that the traits are controlled by one gene with two alleles, where T is dominant to t. MATERIALS AND METHODS Data was collected by 3rd year Genetics students. Blank paper and paper containing PTC was given to a total of 110 people. Each person placed the blank paper in his or her mouth and then the paper containing...
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...Gene One Fund Raising Change in business is constant. How leaders of organizations analyze whether or not their organization will be able to change with the times is critical to a successful business. Gene One is an extraordinary biotech company led by a dedicated and talented leadership team. The company began with an idea and two million dollars, eight years later the company became the first biotech company to eliminate disease in tomatoes and potatoes through biotechnology and is worth 400 million dollars. The purpose of this paper is to introduce two strategies to secure funding through venture capital or IPO that supports the company's goals to introduce new products and continue meeting 40% growth targets. Venture Capital Pursing venture capital is an important step for a rapidly growing business, especially when not seeking an IPO (Inc., 2010). The technology developed by Gene One is already on the market and the industry is experiencing a high level of investor interest that gives Gene One an advantage in the venture capital market. However, targeting the right investors makes a significant difference. Gene One is targeting investors that align with the research philosophies that facilitate the research and development team without having to worry about any private agendas. The research and development team will continue developing the innovative technologies expected, aiding the organization to realize its growth potential, and meeting the minimum...
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...|[pic] |Syllabus | | |School of Business | | |LDR/531 Version 4 | | |Organizational Leadership | Copyright © 2011, 2009, 2008 by University of Phoenix. All rights reserved. Course Description This course prepares students to apply leadership principles to the roles they play as managers. Students will discover more about themselves and will learn more about the connection between the individual and the organization. Other topics include organizational culture, structure, group behavior, motivation, power, politics, organizational change, and workplace conflict. Policies Faculty and students/learners will be held responsible for understanding and adhering to all policies contained within the following two documents: University policies: You must be logged into the student website to view this document. Instructor policies: This document is posted in the Course Materials forum.2+10+ University policies are subject to change. Be sure to read the policies at the...
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...1 Jacob Widner Minter Bio 04 September 20XX Reflection paper Since our last paper we have covered about four chapters. Covering chapters seven, eight, eleven, and 13. All of these chapters have to deal with the human body and what makes the human body what it truly is. Such things as Genes. Genetically modified organisms(GMO), genetics/inheritance, and stem cells. In chapter seven we talked about the structure of human DNA. DNA is a rather complex structure because that's just what it is a double helix structure. Hereditary Molecule are served as an instruction manual for how to build an individual. One DNA molecule has 23 pairs of chromosomes one from each parent. The 23ed chromosome is what determines your sex, you could either be a female XX, or a male XY. Part of the chapter we did a lap on making our own DNA chain. We had to take our supplies and see what traits we had two off and which one was closest to the lines in yo have that trait. Once you made you match you had to cut them out and put them with the other chain to from your DNA linking them together. Chapter eight is about GMO’s. A GMO is where something in the DNA sequence has been altered by humans. Certain things have been changed by humans. Such things as plants. Plants have been changed to help them last in different weather conditions. Such as drought, the desert, or even climates that don't provide the right weather conditions for them to grow. Now 2 ...
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...Henderson 1.When an organism is transfected with a virus, it triggers several mechanisms to protect itself from the viral genes affecting it. Such mechanisms involve the innate immune response of the D. Melanogaster against the virus. Another mechanism that has been discovered not too long ago is the ability of silencing viral genes using an RNA interference pathway. The Argonaute paper has focused on the RNAi pathway of D. Melanogaster. The pathway involves a RISC complex composed of Argonaute 2 , viral siRNA and other proteins that act as a “strike and search” antagonist against viral genes and silencing them. In counter-defense, Viruses try to protect themselves by encoding viral suppressors of RNAi VSR to suppress the RNAi pathway. This leads to an “arms race” of adaptation and counter-adaptation by the host and virus. An important aspect of viral genome is its ability to undergo mutations to protect its self. Viral RNA is capable of antigenic shift and antigenic drift to cause mutations in its own genome and remain adaptable in host environment. The RNA Polymerase of the virus is phage-induced, so it is going to replicate the mutated genome and is different than eukaryotic Polymerase in that manner. In turn, host will evolve according to the viral genome to silence the “new” mutated genes. The evolutionary significance of VSRs in the Argonaute paper has enabled to understand how a conserved protein VP1 from Nora Virus is able to suppress viral siRNA in D. Melanogaster...
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..."Do Our Genes Influence Behavior?" "Do Our Genes Influence Behavior? Why We Want to Think They Do" Chronicle of Higher Education, November 26, 2004 A few weeks ago I was hurrying past a newsstand in Grand Central Station when the cover of the latest issue of Time stopped me short. Superimposed on a painting of a blue-skinned, red-lipped woman, her hands clasped in prayer, were the words "The God Gene." The article within reported that in a new book with that title, the geneticist Dean Hamer had traced belief in God to a specific gene. "Does our DNA compel us to seek a higher power?" Time asked. The article left me pondering a different question: Given the track record of behavioral geneticists in general, and Dean Hamer in particular, why does anyone still take their claims seriously? Behavioral genetics, which attempts to explain what we are and do in genetic terms, began with the English polymath Francis Galton, who in 1883 coined the term "eugenics" to refer to his proposal that humanity improve itself through judicious breeding. Galton's measurements of the physical and mental characteristics of various groups had convinced him that upper-class gentlemen like himself were innately smarter than poor white men, let alone "inferior races" like Africans. On a trip to Africa, however, Galton was mightily impressed with the physical endowments of Hottentot women, whose bodies he measured from afar with a sextant because he was too timorous to approach them. Galton's...
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...2328 alextevi@yahoo.com Olutayo Otubanjo, PhD Senior Lecturer (Marketing) Lagos Business School Pan-African University Km 22 Lekki Epe Expressway Ajah, Lagos, Nigeria. 00234 808 608 6816 totubanjo@lbs.edu.ng Electronic copy available at: http://ssrn.com/abstract=2197664 Abstract Purpose: This paper seeks to create an epistemologically grounded understanding of the causes and process of corporate rebranding via the lens of the theory of evolution by natural selection. Approach: A review of the factors that trigger corporate rebranding, as reported in academic literature, is made. Following the review, a case is made for the absence of an epistemologically grounded understanding of why firms rebrand. Consequently, the theory of evolution by natural selection is brought forward as a platform for the development of a new model that explicates the causes and process of corporate rebranding. Findings: A new model anchored on the theory of evolution by natural selection, and a new definition of corporate rebranding is advanced. Essentially, the model offers epistemologically grounded reasons for ascendancy of corporate rebranding in the environment. Limitations: This is a conceptual paper – meaning that the model suggested in this study is yet to be subjected to a serious empirical exercise Originality: The review of literature indicates the absence of an epistemologically grounded understanding of the causes and process of corporate rebranding in the business environment. The pursuit...
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...How Genetics Influence Down Syndrome PSY 104 Professor Vincent July 7, 2013 How Genetics Influence Down Syndrome Genetics play such an vital role in our development. Every individual carries genes from their mother and their father. Characteristics such as height, eye color, if we have curly or straight hair are all determined through the our genes and specifically our chromosomes. Many times, parents inadvertently pass genes on to their children through their DNA that may contribute to developmental disorders such as Down Syndrome. In this paper, I will explain the role of genetics and how it plays a part in development. I will also explain how the genes of two parents can influence the traits and characteristics of their offspring. Every person has genes and chromosomes located in every cell of their body. Those genes and chromosomes are what make us unique and different. Almost all of a person's traits, from their eye color to what type of hair they will have are coded in their genes (Beck, 2000). Genes and chromosomes come in pairs, with one member of each pair coming at conception from the father and the other from the mother. Normally, at the time of conception a baby inherits genetic information from its parents in the form of 46 chromosomes: 23 from the mother and 23 from the father (Skallerup, 2008). When a child has an extra chromosome for a total of 47 chromosomes instead of 46, they are believed to have Down Syndrome. The genetic material children carry play...
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...desert hedgehog gene is a key gene to the human reproductive system. It plays a vital role in the development of important sexual organs. Along with the other hedgehog proteins, the hedgehog protein family and signaling pathway are also important to the overall development of many parts and systems of the human body. Each protein within the family has its own role to play in overall expression of cells and growth. There are a total of three proteins within the family; the Indian hedgehog (IHH), the sonic hedgehog (SHH), and the desert hedgehog (DHH) gene. The term hedgehog refers to the terminal domains within the genes of this family. The “hog” domain makes up the C-terminal of the gene and the “hedge” domain makes up the N-terminal of...
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...March 20, 2013 CRITIQUE PAPER IN ChE 426N The research paper is entitled “Electricity generation from synthetic substrates and cheese whey using a two chamber microbial fuel cell”. The authors are Georgia Antonopoulou, Katerina Stamatelatou, Symeon Bebelis, and Gerasimos Lyberatos from the Department of Chemical Engineering in the University of Patras in Greece. The research paper is taken from pages 10 to 15 of the Biochemical Engineering Journal, Volume 50. In this study, the possibility of electricity generation from diluted cheese whey in a two-chamber mediator-less microbial fuel cell (MFC) was investigated. The research aims to generate electricity using glucose, lactose, and cheese whey wastewater as substrates. It also aims to compare the performance of a MFC using synthetic sugars, such as glucose and lactose, to that of the same MFC when using raw wastewater, such as cheese whey, as substrate. The title of the article is appropriate and clear in such a way that readers can grasp an idea of the research by just reading it. The abstract is specific and is a representative of the article, although it takes a second look to realize that the research would involve electricity generation from synthetic substrates such as glucose and fructose, and from cheese whey. The research problem is attention-grabbing and timely since there is recently an emerging interest focused on the energy recovery from wastes. Microbial fuel cell (MFC) is gaining promising interest in the research...
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...Implementing a Leadership Change LDR/531 January 31, 2011 Options for Implementing Change In 1996, Gene One entered the biotech industry with groundbreaking gene technology that eliminated disease in tomatoes and potatoes. As a result, farmers no longer needed to use pesticides when growing these plants and consumers were pleased to buy homegrown products untainted by chemicals. Gene One grew from $2 million to a $400 million company in eight years (University of Phoenix, 2011). Gene One’s success also brought with it an increase of stock indices on Wall Street indicative of an augmented interest in the biotechnology field. Leadership changes at the Food and Drug administration increased confidence in investors in the biotechnology field. Don Ruiz and board members believed a 40 percent annual growth target would keep them competitive. Don Ruiz believed the way to acquire additional funding to maximize growth and remain successful would be an initial public offering (IPO) within three years. Upper management and board members varied leadership styles prove to be challenging when considering a replacement for the chief executive officer (CEO) Don Ruiz. Some members of Gene One management team was not in agreement with an initial public offering, expressed reservations. Some members of management expressed concern of managers being deficient in their leadership skills, experience to handle the next level, and suggested terminating these managers...
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...| Cdx regulates Dll1 in Multiple Lineages | BIOL 303 Term Paper | | | BACKGROUND The vertebrate Cdx genes are a group of ParaHox genes that encode homeodomain transcription factors responsible for the anterior-posterior patterning of the embryonic axis, intestine, axial elongation and somitogenesis in mammals. These genes are related to Drosophila caudal (cad)[1] and there are three murine homologues Cdx1, Cdx2 and Cdx4 [2]. The Cdx gene products impact anterior-posterior vertebral patterning not only by direct regulation of Hox gene expression, but are also targets of non-Hox such as Wnt, Shh, RA and Notch pathways among others[3] [2]. The authors focus upon the Notch pathway, especially Notch ligand Dll1 as it is involved in intestinal differentiation. Cdx1 is responsible for the axial positional information and the null mutants have an abnormal axial patterning only and no overt intestinal phenotype [4, 5]. Cdx2 is important for trophoblast differentiation, axial patterning and extension, and morphological specification of gut endoderm [5]. Homozygous Cdx2 null mutants are peri-implantation lethal as the blastocyst fails to undergo uterine implantation [3]. The Cdx1-Cdx2 conditional mutants show an abnormal somite formation and an increase in the number of Goblet cells in the small intestine [2]. Both Cdx1 and Cdx2 are important for the maintenance of the intestinal epithelium in adults. Though there is considerably more information available about the different...
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