..."Perhaps one of the most compelling facts about penicillin is that it went on to save hundreds of thousands of lives during World War II, and has continued to forestall infectious diseases ever since." (Source One, lines 35-38) The strongest drug a person could receive against infections is penicillin. People know what this drug is, but not how it was discovered, developed, and mass produced. Penicillin, one of the most spectacular advances in the medical universe, was discovered and developed by three men; Alexander Fleming, Howard Florey, and Andrew J. Moyer....
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...Running head: SCIENTIFIC DISCOVERY PAPER Scientific Discovery Paper On Penicillin Tracey Ann Elledge University of Phoenix, Las Vegas NV Creative Minds and Critical Thinking PHL 458 Cornell Horn, M.A.; M.A. December 01, 2009 Scientific Discovery Paper Penicillin is an antibiotic that destroys bacteria by destroying the cell wall of the microorganism. It does this by inactivating an enzyme necessary for the cross linking of bacterial cell walls. The enzyme is known as the Tran peptidase. It accepts the penicillin as a substrate, it the alkanolates a nucleophilic oxygen of the enzyme, rendering it inactive. Cell wall construction stops and the bacteria soon die. The antibiotic nature of the penicillin so due to the strain lactam ring, on opening the ring strain is relieved this makes penicillin more reactive than ordinary amides. Before penicillin a simple pinprick or tiny cut could have been lethal. There are so many people easily catching infections that would rage out of control. Children died regularly from scarlet fever, from infections of the bones, throat, stomach or, brain. Many of us would not be here today had it not been for the discovery of penicillin. In 1928, Alexander Fleming made a chance discovery from an already discarded, contaminated Petri dish. The mold that had contaminated the experiment turned out to contain powerful antibiotic, penicillin. However, though Fleming was credited with the discovery, it was over a decade...
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...diffraction to study DNA. Crick and Watson used their findings on their own research and in April 1953 they published the news of their discovery, a molecular structure of the DNA based on all of its features. Their model served to explain how DNA replicates and how hereditary information is coded on it. This set the stages for rapid advances in molecular biology which continues until this day. In the other partnership with Rosland and Franklin, Franklin produced an X-ray photo that allowed Crick and Watson to work out the 3D structure of DNA. The structure of the DNA was found to be a double helix. Watson, Crick and Wilkins shared a Nobel peace prize in medicine in 1962. Franklin had died in 1958 and despite her hard work the prize could not be received posthumously. Another way in which science and technology advanced medicine since 1750 was the development of penicillin. In 1928, Alexander Fleming whilst studying influenza noticed that mold had developed accidently and completely by chance on a set of culture petri dishes used to grow staphylococci germ. The mold on the petri dishes created a bacteria free circle around itself. He then experimented further and made the mold into some sort of medicine and named the substance penicillin. Fleming wrote down his discovery and published it. However, Fleming did not realize the potential of this remarkable discovery of a drug. Therefore, no further research was carried out due to lack of funding and specialist help. Howard Florey...
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...uses, see Alexander Fleming (disambiguation). Sir Alexander Fleming FRSE, FRS, FRCS(Eng) | | Born | 6 August 1881 Lochfield, Ayrshire, Scotland | Died | 11 March 1955 (aged 73) London, England | Nationality | Scottish | Fields | Bacteriology, immunology | Alma mater | Royal Polytechnic Institution St Mary's Hospital Medical School Imperial College London | Known for | Discovery of penicillin | Notable awards | * FRS (1943)[1] * Nobel Prize (1945) * Knight Bachelor (1944) | Signature | Sir Alexander Fleming, FRSE, FRS,[1] FRCS(Eng) (6 August 1881 – 11 March 1955) was a Scottish biologist, pharmacologist and botanist. He wrote many articles on bacteriology, immunology, and chemotherapy. His best-known discoveries are the enzyme lysozyme in 1923 and the antibiotic substance penicillin from the mould Penicillium notatum in 1928, for which he shared the Nobel Prize in Physiology or Medicine in 1945 with Howard Florey and Ernst Boris Chain.[2][3][4][5][6][7] Contents * 1 Early life and education * 2 Research * 2.1 Work before penicillin * 2.2 Accidental discovery * 2.3 Purification and stabilisation * 2.4 Antibiotics * 3 Myths * 4 Personal life * 5 Death * 6 Honours, awards and achievements * 7 See also * 8 Bibliography * 9 References * 10 External links Early life and education Fleming was born on 6 August 1881 at Lochfield farm near Darvel, in Ayrshire, Scotland. He was the third...
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...ear, or the nervous system causing pneumococcal meningitis. Pneumococcal meningitis has a high fatality rate when compared to the other infections caused by Streptococcus pneumoniae. The means of transmission of Streptococcus pneumoniae is via respiratory droplet from the mouth or nose of an infected person or a carrier. Penicillin became available in the 1940’s which changed radically the treatment of pneumococcal pneumonia which was based on watchful waiting. Despite this major development pneumonia still posed a major clinical problem today because of the resistance the organism developed against anti -microbial agents.Penicillin resistance is caused by a mosaic mutation of penicillin binding Protein (PBP) genes due to interspecies recombination of homologous genes. It is also recognized that a penicillin resistant pneumococcal in most cases is resistant to other antibiotics such as macrolide, tetracycline, co-trimoxazole, chloramphenicol and clindamycin.Antimicrobial resistance have limit the choice of treatment for many pneumonococcal diseased because of resistance these organism have built up against a number of antibiotice.For instance penicillin is said to be resistant to a list of...
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...Ethics Paper The Tuskegee syphilis experiment was an infamous clinical study conducted between 1932 and 1972 in Tuskegee, Alabama by the U.S. Public Health Service to study the natural progression of untreated syphilis in rural black men who thought they were receiving free health care from the U.S. government. The Public Health Service, working with the Tuskegee Institute, began the study in 1932. Investigators enrolled in the study a total of 600 impoverished sharecroppers from Macon County, Alabama; 399 who had previously contracted syphilis before the study began, and 20 without the disease. For participating in the study, the men were given free medical care, meals, and free burial insurance. They were never told they had syphilis, nor were they ever treated for it. According to the Centers for Disease Control, the men were told they were being treated for "bad blood", a local term for various illnesses that include syphilis, anemia, and fatigue. The 40-year study was controversial for reasons related to ethical standards; primarily because researchers knowingly failed to treat patients appropriately after the 1940s validation of penicillin as an effective cure for the disease they were studying. Revelation of study failures by a whistle blower led to major changes in U.S. law and regulation on the protection of participants in clinical studies. Now studies require informed consent (with exceptions possible for U.S. Federal agencies which can be kept secret by Executive...
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...Disease in the News Paper Phillip Moore HCS/330 3/4/2015 Dr. Talbert Disease in the News Paper Syphilis represents a sexually transmitted disease with a long history of infection, disability and death. The disease starts with a simple chancre and morphs into a contagion that attacks the nervous system. The history of the disease covers continents and spans oceans. Today, the disease exist as a medical footnote and as an unfortunate experiment best forgotten. However, the disease refuses to go away. This paper will examine the return of the disease and the demographic the disease attacks. First, let us learn a little bit about the history of the disease. Syphilis usually transmits sexually through small abrasions found within the mucosal membranes or through the layers of the skin. Syphilis enters the system and flows through the bloodstream to spread throughout the body. People carrying the lesions associated with the onset of syphilis usually transmit the disease (Ho, E. and Lukehart S., 2011). The chances that an exposed person may contract Syphilis is about 30% (Ho E. and Lukehart S., 2011). However the range may extend between 10% - 80%). Before the discovery of penicillin, the cure for syphilis did not exist. Patients with the disease suffered through the various stages of the disease until they died. One famous syphilis victim was the notorious gangster Al Capone. The discovery of penicillin changed the fatal outcome of the syphilis disease....
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...that discusses unethical business research conduct that has resulted in individuals or a firm being convicted, or at least tried for, this conduct. Some examples include the following: • Asking inappropriate questions • Skewing research results • Failing to maintain participants’ confidential information • Using participant information for unintended purposes such as selling goods or services Summarize the article you researched. Write a 750-word paper in which you address the following questions: • What unethical research behavior was involved? • Who were the injured parties? • How has the unethical behavior affected the organization, the individual, and society? • How could the unethical behavior be avoided or resolved? In the 1932 case of the Tuskegee Syphilis Study was a 40-year project administered by the US Public Health Service in Macon County, Alabama. The study consisted of 400 men being promised free treatment for an epidemic of bad blood in their county. The treatment was withheld from the men and was never given. The study was tested on a group of African American men who were told they had bad blood and never received standard treatment for syphilis,. Syphilis is a sexual transmitted disease. It can lead to a range of painful, chronic and deadly symptoms, such as infection in the nerve-system, or cardiovascular-complications. Even-though the cure of penicillin was available the men were never informed of the research design or it's risk to them. What...
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...Tuskegee Study Ezequiel W. Ferreras EN1320 - Composition 1 ITT Technical Institute ABSTRACT This paper is to prove how the Tuskegee study was morally and ethically wrong. Many of the men involved in the study died due to the experiments. This study has made it important for all patients to understand their options for treatment and outcomes and know that they have a choice. Any one can deny treatment if they wish to do so. Many doctors devote their lives to their patients and have learned from this major medical error. Tuskegee Study Some people may believe they don’t need to try as hard if they already achieved their goal, but if a physician does not do their best a patient can die and if no one did their best then there would be no doctors, lawyers or even teachers. However, when you apply the unethical concepts in this study it violates the professional code of ethics and the moral reasoning of the study. Albeit it is for a test to make history the obligations of a nurse are very important and must be followed. In Miss Evers’ Boys, physicians investigate in a medical study that takes place in Tuskegee Alabama, which dealt with watching African-American subjects discover the effects of untreated syphilis. The major objective of the study was to search for African-American males in the second stage of syphilis, and then from time to time perform exams on these men to find out the effects that syphilis had on their bodies. (Grey 1998) Raymond A. Vonderlehr...
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...Medical Experimentation on African Americans Katryna A. Lawson Montgomery College Abstract This research paper is going to review some of the horrific ways that African Americans were abused by medical research experiments in the United States. I will also examine how America’s physicians has a disgraceful history of exploitative studies in which African Americans have been used as objects, for new surgical techniques, drug testing, nuclear radiation absorption, biased psychological testing, sterilization, and cadavers all in the name of medical science since the time of slavery. Medical experimentation on African Americans began during the time of slavery. The South was home to 90 percent of American blacks, in some states, the black population was completely comprised of slaves: Alabama, for example, forbade the presence of free blacks. Since there was so many slaves, this also made the south a haven for the lowest of the low, worst kind of medical experiments on African Americans. Harriet A. Washington, author of the book Medical Apartheid: The Dark History of Medical Experimentation on Black American from Colonial time to the Present, cites many of the atrocious acts that the Black Americans experienced through telling personal stories like those of slave women, giving faces to many of the black victims of violent medical experimentation and racially biased investigations, while also revealing the doctors inflicting the abuse. Doctors tortured and abused African American...
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...Unethical Research Practices Unethical research is commonly found within pharmaceutical companies. In a hurry to get new drugs to market, companies will often cut corners during the research process. Pharmaceutical companies will spend millions of dollars on drug research, but very little on unethical drug promotion (Parmar, Jalees, 2004). The purpose of this paper is to inform the reader of how unethical research practices can lead to death from both past and present case studies. Present Rizwan Rahim Ahmed and Dr. Ahmed Saeed conducted a case study concerning ethical and unethical pharmaceutical marketing practices in Karachi City, Pakistan (Ahmed, Saeed, 2012). The results were very alarming to the world. The study indicated that doctors, hospital administrators, and pharmacies were receiving kickbacks from the pharmaceutical industry for prescribing their drugs to patients. The case study concluded that participants had different levels of blame. For example, the study shows that four out of five doctors were receiving money from these companies. Still today the government of Pakistan turns a blind eye to this type of unethical behavior. Research found that doctors were prescribing unnecessary drugs to patients regardless of the medical outcome. The more medicine they prescribe, the more money they would receive from the pharmaceutical companies. The study concluded that this type of unethical practice is common throughout the world but severe with regard to developing...
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...twenty-seven of the study’s original participants were still alive and had not died from the disease (Morehan, 2007). In the film, the story is told from the view point of Nurse Eunice Evers, one key character in the movie, who played the role of the real- life nurse who was a part of the Tuskegee Study. The movie, Miss Evers’ Boys portrays “the emotional effects of one of most amoral instances of governmental experimentation on humans ever perpetrated” (Morehan, 2007). It depicts the government’s involvement in research targeting a group of African American males, as it explores the depths of human tragedy and suffering that result from unethical act. The film also unveiled the racial tension that existed in America which did not only occur in the segregation of skin color but also founded upon disease (Morehan, 2007). The purpose of this paper is to analyze the film in order to critically examine bioethical issues in healthcare, research, and nursing. This paper focuses on the ethical frame-works virtue based ethics, right based ethics, justice based ethics, duty based ethics and it also reveals the roles and behavior portrayed by the main characters and also that of the scientific community and society. Summary of Film The film begins with Eunice Evers, an elderly nurse reciting the nurses’ oath...
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...Centre Number For Examiner’s Use Candidate Number Surname Other Names Examiner’s Initials Candidate Signature Question General Certificate of Education Advanced Subsidiary Examination June 2009 Mark 1 2 3 Biology Unit 2 BIOL2 4 5 The variety of living organisms 6 Thursday 4 June 2009 1.30 pm to 3.15 pm 7 8 9 For this paper you must have: G a ruler with millimetre measurements. You may use a calculator. TOTAL Time allowed G 1 hour 45 minutes Instructions G G G G G G Use black ink or black ball-point pen. Fill in the boxes at the top of this page. Answer all questions. You must answer the questions in the spaces provided. Answers written in margins or on blank pages will not be marked. You may ask for extra paper. Extra paper must be secured to this booklet. Do all rough work in this book. Cross through any work you do not want to be marked. Information G G G G The maximum mark for this paper is 85. The marks for questions are shown in brackets. Quality of Written Communication will be assessed in all answers. You will be marked on your ability to: – use good English – organise information clearly – use accurate scientific vocabulary where appropriate. (JUN09BIOL201) APW/Jun09/BIOL2 BIOL2 2 Areas outside the box will not be scanned for marking Answer all questions in the spaces provided. 1 The diagram shows some of the large blood vessels in a...
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...is the temperature at which its usual is known to be at regular body temperature. It also grows in beer as well as its growth in dairy products and can be transmitted consumption of milk (sciencedirect.com). The bacterium also colonizes the human mouth, mucosae, oropharynx and upper respiratory tract. Although once regarded as non-pathogenic, it is now considered an opportunistic pathogen, especially in patients with a compromised immune system. It is also responsible for an infection that can be originating from a hospital.In hospitals, the bacteria can be transmitted by hospital staff who may have failed to wash their hands properly by going from one patient to another. It was discovered by Sir Alexander Fleming before he discovered Penicillin in 1928...
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...Pharmacology Phunland When people go to an amusement park, what do they look forward to the most? Cool rides? Great food? How about learning in a themed atmosphere? At Pharmacology Phunland, you’ll get all three! Your family will have a blast in our park while learning all about medicine advances in the 20th century. There are three sections, all with their own specified theme and rides. Additionally, there are two cool restaurants in which your family can enjoy exotic foods. Learn all about the deadly virus in Polio Park! Featuring fun for the whole family, along with a valuable learning experience, Polio Park is themed around the highly infectious virus that swept the world. Being depicted as early as pre-history, polio is a virus that can affect the central nervous system and lead to the destruction of the motor neurons. This can lead to muscle weakness and paralysis. Before the 20th century, polio was found mostly in children between 6 months and 4 years old. However, before the mid-19th century, people who lived in poorer sanitation areas were constantly exposed to the virus, thus creating immunity. By the early 20th century, huge improvements were made in community sanitation. This lead to a pandemic outbreak of polio in Europe, North America, Australia, and New Zealand during the first half of the 19th century. By the mid-1950s, there were not one but two different versions of the polio vaccine. This cut polio outbreaks drastically. In this park, all of the rides have...
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