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Protein Structure-Task 2

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Protein Structure
Horacio Madera
Western Governors University
-C624

July 2, 2015

A. Original model of the essential amino acid Threonine.

B. Original diagram of the different levels of protein structure.

C. Original diagram demonstrating how a peptide bond is made through dehydration.

D. Original diagram that demonstrates how a peptide bond is broken through hydrolysis.

E. Explanation of the four forces that stabilize a protein’s structure at the tertiary level of protein structure.

Disulphide bridges are form very strong covalent bonds that are found in between Sulphur atoms in the amino acid cysteine molecules.
Ionic bonds occur between a carboxyl and amino group that is not involved in a peptide bond.
Hydrogen bonds result from the bonding of an electronegative oxygen atom and electropositive H atom. Hydrogen bonds can occur in either –OH or –NH groups.
Hydrophobic interactions are created from certain non-polar hydrophobic amino acids that move to the center of the protein and away from the watery medium. This results in twists or folds of the polypeptide chain.

Toole, G., & Toole, S. 2004, p. 38. Essential As Biology for OCR ( ed.). Cheltenham, United Kingdom : Nelson Thornes Ltd.

F. Bovine spongiform encephalopathy (BSE) at a molecular level. Part F-Disease at the Molecular Level * Bovine spongiform encephalopathy (BSE) is an infectious disease that is known as Mad Cow Disease. * The disease is primarily transmitted to cattle by consumption of meat and bone meal (MBM) contaminated with an infectious protein named prion (PrPSc). * Animals infected with the prion are sometimes sacrificed and used as fed propagating further BSE.

Part F1-Role of Misfolding and Aggregation * Misfolding is the...

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