...Nov. 2011 Psoriasis “Psoriasis is a common skin disease that affects the life cycle of skin cells. Psoriasis causes cells to build up rapidly on the surface of the skin, forming thick silvery scales and itchy, dry, red patches that are sometimes painful” (mayoclinic.com). The word psoriasis was derived from the Greek word psora which means “to itch.” It is neither contagious nor infectious. Though the exact cause of psoriasis is unknown, it is know that the immune system and genetics are major factors in the development of this skin disorder, as well as triggers, which might excite the growth of skin cells. Even though psoriasis only affects about 2-3 percent of the global population, it is one of the most common skin disorders and reason people go to see a dermatologist. Studies show that psoriasis shows up equally among men and women and can appear at any age, but typically between the age of 15 and 35 years. The most common places for psoriasis to appear are the scalp, elbows, knees, and torso, but are not limited to those areas; palms, soles, genitals, nails and although it is rare, the face, anywhere there is skin psoriasis can develop. The psoriasis patches, also known as lesions, general appear symmetrically meaning that if it appears on the left side it will more than likely appear on the right side of the body as well. Not all psoriasis is created equal and can be localized or widespread over the entire body. There are five different types of psoriasis. The different...
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...Psoriasis is a common skin disease that affects the life cycle of skin cells. Psoriasis causes cells to build up rapidly on the surface of the skin, forming thick silvery scales and itchy, dry, red patches that are sometimes painful. Psoriasis is a persistent, long-lasting (chronic) disease. You may have periods when your psoriasis symptoms improve or go into remission alternating with times your psoriasis worsens. For some people, psoriasis is just a nuisance. For others, it's disabling, especially when associated with arthritis. There's no cure, but psoriasis treatments may offer significant relief. Lifestyle measures, such as using a nonprescription cortisone cream and exposing your skin to small amounts of natural sunlight, can improve your psoriasis symptoms. The cause of psoriasis isn’t fully known, but it's thought to be related to the immune system and its interaction with the environment in people who have the genetic susceptibility. More specifically, one key cell is a type of white blood cell called a T lymphocyte or T cell. Normally, T cells travel throughout the body to detect and fight off foreign substances, such as viruses or bacteria. If you have psoriasis, however, the T cells attack healthy skin cells by mistake, as if to heal a wound or to fight an infection. Overactive T cells trigger other immune responses. The effects include dilation of blood vessels in the skin around the plaques and an increase in other white blood cells that can enter the outer layer...
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...Psoriasis comprises red, scaly patches of skin, which usually have very well defined edges, appear covered by silvery flaky surface [1]. These patches, which are sometimes referred to as plaques, usually itch or feel sore. The redness is explained by impressive growth and dilation of superficial blood vessels [2]. They most often occur on the elbows, knees, other parts of legs, scalp, lower back, face, palms, and soles of the feet, but they can occur on skin anywhere on the body [3]. The disease may also affect the fingernails, the toenails, and the soft tissues of the genitals and inside the mouth [4]. It is often symmetrical, affecting both sides of the body. Psoriasis is often so mild it is barely noticed by the affected person, but it can occasionally be so severe that the patient must be admitted to hospital for treatment. The disease occurs in all age groups, primarily affecting adults. The most common ages for psoriasis to first appear are in the late teens and in the 50s. It affects men and women equally, although in children, girls are more commonly affected than boys [5]. Being characterized as dermatological disease, psoriasis is a non- contagious lifelong skin disease and also not an outcome of poor hygiene. Unfortunately it is often overlooked or dismissed because it is not typically life threatening [6]. Depending on the variability in morphology, distribution, severity and cause, they are divided into different types. Some can occur independently or at the same...
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...Psoriasis: More than skin deep HCS 245 January 10, 2010 Psoriasis is a noncontagious common skin condition that causes rapid skin cell production resulting in red, dry patches if thickened skin. Although, psoriasis is classified as dermatologic disease, it doesn’t start in the skin, and its damage may be more than skin deep. In fact, the very name is borrowed from an ancient Greek word meaning an itchy or scaley condition. Psoriasis is a chronic condition that strikes both male and female from infancy to the elderly. It can range from mild to severe. Environmental factors play a role; psoriasis has been linked to psychological stress, obesity, smoking, alcohol, strep throat, viral infections, lack of sunlight, and certain medications (antimalarial drugs, lithium, beta blockers, etc.) Psoriasis comes in many forms and about 90% of patients have the plaque type, which is sharply demarcated salmon-pink plaque of inflamed skin covered by silvery scales(July, 2010). Other types of psoriasis include: • Guttate psoriasis- The second most common form of psoriasis. Gutta means droplet. Patients have numerous small, red, scaley spots scattered on the arms and legs. The trigger to the disease is usually a streptococcal (bacterial) infection. The eruption of the lesions on the skin usually happens about 2-3 weeks after the person has strep throat. The outbreak can go away and not reoccur. Outbreaks may also go away and come back, particularly if the person is a strep carrier...
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...What are scientist doing to solve the problem of psoriasis? Psoriasis is an immune-mediated disease , which is abnormal activity of the body's immune system, in which the T-cells behave abnormally this then affects the skin.(1) Psoriasis happens when the skin replacement process speeds up, taking just a few days to replace skin cells that usually take 21-28 days, the skin cells build up , instead of shedding the extra skin cells they form raised areas on the skin, which can be flaky, scaly or red. (2)There is not a fully understood cause of psoriasis, but it is believed to have a genetic component, and is believed to be triggered by stress and/or injury to the skin.(3)It’s also believed that people with psoriasis have an increased risk of cardiovascular disease. The main solution, have you heard of phototherapy? Evaluation of reference one: Reference one is a reliable source because it is registered charity, this is updated by medical trustees who are qualified in dermatology. This information is not biased either, this is also because of the fact that it is from a medical point of view so there are only facts stated. This information is up to date too because the charity needs to keep people updated regularly with any new information that may occur. Evaluation of reference 4: Reference four is a reliable source because it is a national foundation which means lots of people will be viewing what they are saying so they must have their facts correct. Their information is updated...
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...Patient expectation Patient expectation Treatment plan * Demonstration to patient * Drugs/systematic oral medication * Psychological support * Types of severity * Follow up: blood investigation, psoriasis lesion * Topical creams/emollient * Adverse reactions/side effects Management 1. Topical 2. Systematic 3. Phototherapy a. Narrowband UVB and PUVA b. UVA Treatment plan * Demonstration to patient * Drugs/systematic oral medication * Psychological support * Types of severity * Follow up: blood investigation, psoriasis lesion * Topical creams/emollient * Adverse reactions/side effects Management 4. Topical 5. Systematic 6. Phototherapy c. Narrowband UVB and PUVA d. UVA Diagnosis * Prognosis * Cure rate * Quality of life * Further investigation Differential diagnosis * Good investigation – biopsy Diagnosis * Prognosis * Cure rate * Quality of life * Further investigation Differential diagnosis * Good investigation – biopsy Summary and results * Quality of life * Other scores * Symptomatic relief Summary and results * Quality of life * Other scores * Symptomatic relief Follow up Evaluation at 3 months and 6 months Follow up Evaluation at 3 months and 6 months Consultation * Psychological support * Prognosis * Stress and life style management Consultation * Psychological support * Prognosis * Stress and...
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...Skin Conditions Student’s Name Institution of Learning Introduction The society requires attaining, maintaining, and recovering from disease, ailments accidents. It calls for specialized care from a trained professional. In most of the cases, care givers at home may lack this expertise. It requires people who are trained and specialized, and who understand the medical aspect of the patients’ condition. The best suited group of people that can deal appropriately with these problems are nurses. Nursing is a health care profession and hence, their services are oriented to this direction. In their duty, they give care to all members of societies; both individual and families (Braverman, 1998). Nursing care is understood as being particularly crucial during patients’ recovery from serious illness or injury. Classically, it was thought that people requiring these services were probably people who were bed ridden. The objective of health services delivery is not only to care for bed ridden people but also anybody else that have a condition that is reducing their quality of life. It is known that some diseases significantly reduce the quality of life. Today, the aim of healthcare is to assist any person with any disease, ailment, or any form of suffering to recover and have a joyous and creative life. Another factor that makes a nurse to be specifically suited to their job is because they are trained about community care. They deliver...
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...CONTAINING AZITHROMYCIN AND PREDNISOLONE VESICLES FOR TREATING PSORIASIS Sonia Tomar, Tinku Singhal, ABSTRACT Psoriasis is a chronic, autoimmune systemic inflammatory disease, associated with metabolic syndrome, cerebrovascular disease, diabetes and many other diseases. There is various type of psoriasis but most common type of psoriasis is caused by Psoriasis vulgaris. It is characterized by rigid of skin due to increase in the level of cholesterol and fall in the level of ceramide. Apart from that it is associated with an immune system of the body means movement of immune cells from dermis to the epidermis, where they stimulate skin cells (keratinocytes) to proliferate. Various type of drug delivery system are used for the treatment of psoriasis including topical, oral or systemic but gels prepration of azithromycin and prednisolone are more effective in reduction of purities, scaling and hyperkeratosis of psoriasis plaque. Niosomal/Vesicular gel, has been explored extensively for topical application to enhance skin penetration as well as skin retention. Prednisolone and azithroycin together provide effective results in the treatment of psoriasis. Due to high entrapment efficiency and stability, gel prepration (Azithromycin & Prednisolone) reduce the scaly patches and suppression of humoral immunity. Keywords: Niosome, Immunity, Topical, Psoriasis, Gel, Azithromycin, Prednisolone. INTRODUCTION Psoriasis is recognized as a complex, chronic skin condition that can...
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...Dead Sea Vacation! One of my favorite things! I’m pretty sure that most of you, if not all of you, love vacation too! Yet, every one has different ideas of what they like vacation to be. • Some people like to go away to a place with a cold climate and a lot of snow. They like to ski, snowboard, and relax in a cabin sitting by the fireplace. • Others prefer going to a place with a warm climate where they can just lazy around, sit outdoors, swim, and bask in the sun. Personally, I like the warm climate much more. One such place that I’ve been to and is a vacation spot for people all around the world is the Dead Sea. Although we know that there’s a history behind the Dead Sea, that is not what makes it such a hot vacation spot. What draws people from all over are, the benefits the Dead Sea has to offer. Today I’m going to share with you a couple of these benefits. The Dead Sea is often referred to as the Living Dead Sea. (The Living Dead Sea you might ask?) Isn’t that an oxymoron? It’s called the Living Dead Sea due to the ways it can treat and sometimes even cure certain diseases. It can definitely help improve the quality of ones life. Around the world many health spas have benefits relating to climate, water, and air. The Dead Sea is the only place that combines them all. The air, water, and temperature of the Dead Sea causes it to have a very therapeutic effect on its visitors. Firstly, the region has an enriched oxygen atmosphere. It...
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...Psoriasis is an autoimmune disease that affects the skin. A lot of autoimmune diseases attack healthy cells and cause inflammation in the body. Unfortunately, psoriasis not only can affect your skin, research has shown it can affect your heart as well. Because of the increased amount of inflammation in your body researchers believe this can lead to an “increased chance of heart attack or stroke.” If you have psoriasis it is imperative to monitor your heart health and take steps to prevent heart disease. In order to try and avoid having such complications routine checkups, diet, and exercise can help improve or slow down the progression of the disease, researchers believe. Even though psoriasis is an unpredictable disease and it is difficult...
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...Research Journal: Pemphigus and pustular psoriasis This case report and review involved a woman who had been diagnosed with pemphigus foliaceus (PF). Several types of blisters and lesions, and in some cases, psoriasis vulgaris are symptoms of this autoimmune disease. This case study sought to determine if there is a pathological connection between PF and generalized pustular psoriasis (GPP). This patient was first admitted in 2014 with exacerbated symptoms including “extensive bullae, erosions, scales and crusts on the scalp, face, trunk and limbs…” (Abbas, 2017) Cultures, lab tests and a biopsy were conducted, with only the erythrocyte sedimentation rate (ESR) showing as elevated as well as white blood cell abnormalities. She was diagnosed...
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...HELP pls Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile Smile...
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...pathophysiology of two diseases namely Psoriasis and the Human Immuno-Deficiency Virus (HIV). Basically, psoriasis is an autoimmune inflammatory disease which is said to be complex. The disease is mainly common among individuals who are genetically susceptible and is mainly presented by the inflammatory plaques which develop on one’s skin. Apart from genetic susceptibility, psoriasis is also caused when the immune system mistakes viable cells to be external components. In the past few decades, the pathogenesis of this disease was mainly said to be keratinocyte hyperproliferation. Currently, the pathogenesis of the disease also focuses on the dysregulation of one’s immune system. Primarily, the inflammatory plaques appear as silver-white patches. Conversely, the pathogenesis of HIV is basically attributed to by the extensive degradation of one’s immune system. The HIV pathogenic mechanism is prompted by the presence of HIV virus in one’s immune system. The weakening of the immune system culminates in increased susceptibility to various infections (Dann, 2009). Differences There are major evident differences between the two maladaptive responses of the given diseases. For instance, the two diseases result in different ramifications upon one’s immune system. While HIV tends to weaken one’s immune system, psoriasis does not do the same. In addition, it is evident that the two maladaptive responses differ simply by evaluating the symptoms of each. Psoriasis is depicted through the skin abnormalities...
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...Is Apremilast a safe and effective alternative to use in patients presenting with moderate to severe plaque psoriasis who qualify for phototherapy or biologics? Background: Plaque psoriasis is a chronic autoimmune condition that appears on the skin and presents as patches of thick, red, itchy, and scaly skin, particularly on the scalp, elbows, and knees.6,9 Psoriasis is a serious medical condition and affects approximately 7.5 million individuals.3 The current treatment regimen for moderate to severe plaque psoriasis consists of systemic agents, phototherapy, or biologic agents. Apremilast is the first oral drug to receive FDA approval (march 21, 2014), it is an oral phosphodiesterase 4 inhibitor (PDE4) which works intracellularly to prevent the breakdown of cyclic adenosine monophosphate (cAMP) which is important for cellular processes such as inflammation, and it prevents pro-inflammatory cytokine production. Apremilast inhibitors tumor necrosis factor-alpha (TNF-alpha), interferon-gamma, and interleukinds-12, 23 and others. It is important to determine if apremilast can be used as an alternative therapy for patients who are not responding to biologics or phototherapy, and those who...
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...Aloe Vera: History, Science, and Medicinal Uses Presented by www.HealingAloe.com Many people are looking to nature for answers to their present health challenges. Aloe has never been more popular as a natural and holistic approach to many of today‟s modern diseases. People across the world with Diabetes, Arthritis, Gout, Psoriasis, Irritable Bowel Syndrome (IBS), Ulcers, Inflammation, and other conditions are looking to Liquid Aloe Vera for help. Even more people believe “an ounce of prevention is worth a pound of cure”, and numerous scientific studies on Aloe Vera are demonstrating its analgesic, anti-inflammatory, wound healing, immune modulating and anti-tumor activities as well as antiviral, anti-bacterial, and antifungal properties. Aloe‟s medicinal properties can be attributed to the synergistic effect of the combined nutritional elements producing a more powerful effect than the individual components. This book will serve to educate and inform you as you decide to make Aloe part of your daily health program. CONTENTS 1 2 3 4 5 6 7 8 9 10 Historical Information Early Medicinal Uses Preparation for Use Nutritional Overview of Aloe Medicinal Benefits External Healing Internal Healing Maximize Your Benefits What‟s Next? References 2 2 3 5 7 8 8 11 11 12 www.HealingAloe.com 1 1. Historical Information Aloe Vera (Aloe barbadensis Miller) is a specific species of Aloe. There are over 400 species of Aloe Vera plants in the Lily Family. Aloe plants tend to grow...
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