...Sickle cell anemia(SCD) is an inherited genetic disorder which causes the expression of defective hemoglobin on chromosome 11 resulting irregularly shaped red blood cells also known as “sickle cells” because they look like a sickle or are in a crescent shape. The normal red blood cells are round, smooth and deliver oxygen to cells throughout the body but a cluster of sickle shaped cells blocks the blood flow, causing painful attacks and sometimes stroke. Due to their different shape and chemistry, they are controlled by many free radical processes. This paper will talk about the frequency this disease, inheritance pattern, genetic changes, current research and/or efforts to develop vaccine, symptoms, diagnosis and treatment of sickle cell anemia....
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...Sickle Cell Anemia Sickle Cell Anemia is a condition where it’s not enough healthy red blood cells, which carry adequate oxygen throughout your body. Normally our Red Blood Cells are flexible and round and move easily through the blood vessels. In Sickle Cell Anemia, the red blood cells get rigid and Sticky and they become shaped like a little crescent moon. The irregularly shape cells can get stuck in small blood vessels, which slows or blocks blood flow and oxygen to parts of the body. A way to tell how you have Sickle Cell Anemia is periodic pain, called crisis are a major symptom of Sickle Cell Anemia. This pain can last for hours or even weeks at a time. Painful swelling of hands and feet. Frequent...
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...report I want to talk about sickle cell anemia. Sickle cell anemia is a blood disease that changes the shape of the red blood cells from the circular shape to the shape of the crescent. The shape of the sickle changes into a crescent, which is difficult to pass through the small blood vessels. When this occurs, it is difficult to enter oxygen throughout the body. Hemoglobin is an iron-rich substance that makes blood red and allows red blood cells to carry oxygen from the lungs to all parts of the body. The abnormal hemoglobin causes red blood cells to be rigid, sticky and deformed. The father and mother must transmit the defective form of the gene in order for the child to be affected. If a parent transports the gene, the child will have some cells that have been...
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...This paper will describe what sickle cell anemia is, how it effects the human body; as well as the oral cavity. Sickle cell anemia is a hereditary disease caused by abnormal hemoglobin, which causes the red blood cells to have low oxygen levels (National Heart, Lungs and Blood Institute, 2015). Sickle cell anemia is inherited only if both parents have the disorder because it is caused by the genetic abnormality of hemoglobin (webMD, 2015). When there is abnormal hemoglobin it can produce sickle hemoglobin (webMD, 2015). This causes the red blood cells to stick together and create long rod shaped red blood cells when oxygen leaves the cell (webMD, 2015). When this happens it causes the symptoms of sickle cell anemia (webMD, 2015). In people...
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...Eastern Shore Sickle Cell Anemia Dayona Williams Developmental Psychology 0301 Evelyn Jones 25 November 2014 Abstract: The paper you are about to read will inform you about the disease Sickle cell Anemia. It will explain to you about what Sickle cell Anemia is and how you develop it. This paper will also tell you the symptoms and who can get it. While reading the information you will understand all about the disease and how it’s treated and can it be cured. Also in the paper it will inform you about the difference in Sickle cell Anemia and Sickle cell Trait. Lastly, In the paper you are about to learn all you need to know if someone in your family has Sickle cell Anemia and what they go through and how to actually understand it. In today’s society many kids and adults face the disease called Sickle-cell Anemia. This disease is well known throughout many states and countries. Sickle-cell Anemia is when red blood cells are not shaped as normal blood cells. They are shape in a crescent moon like shape which creates different blockages from the normal cells to pass through. The reason why is because the actual sickle cells become sticky to the point where they stick on the blood vessels wall. Many people know that red blood cells carry nutrients and oxygen from the lungs throughout the body. With the blood vessels flow being blocked and the blood cells shape being crescent there is not enough oxygen being pushed through the body. The red blood cell also carries, “iron...
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...Sickle Cell Disease is an illness that affects people all across the globe. This paper will give a description of the sickness through the discussion of the causes, symptoms, and possible cures. Sickle Cell Disease (SCD) is a "group of inherited red blood cell disorders."(1) These disorders can have various afflictions, such as pain, damage and a low blood count--Sickle Cell Anemia. Sickle cell disease is the most common inherited blood disorder in the United States. Approximately 80,000 Americans have the disease. In the United States, sickle cell disease is most prevalent among African Americans. About one in 12 African Americans and about one in 100 Hispanic Americans carry the sickle cell trait, which means they are carriers of the disease. Sickle cell disease is caused by a mutation in the hemoglobin-Beta gene found on chromosome 11. Hemoglobin transports oxygen from the lungs to other parts of the body. Red blood cells with normal hemoglobin (hemoglobin-A) are smooth and round and glide through blood vessels. In people with sickle cell disease, abnormal hemoglobin molecules - hemoglobin S - stick to one another and form long, rod-like structures. These structures cause red blood cells to become stiff, assuming a sickle shape. Their shape causes these red blood cells to pile up, causing blockages and damaging vital organs and tissue. Sickle cells are destroyed rapidly in the bodies of people with the disease, causing anemia. This anemia is what gives the disease...
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...Sickle Cell Disorder Research Paper Sickle cell anemia is a disease passed down through families in which red blood cells form an abnormal sickle or crescent shape. Red blood cells carry oxygen to the body and are normally shaped like a disc. Sickle cell disease refers to a group of inherited red blood cell disorders. It is the most common genetic disease in the U.S. An estimated 70,000-80,000 Americans have sickle cell disease. Normal red blood cells are round like doughnuts, and they move through small blood tubes in the body to deliver oxygen. Sickle red blood cells become hard, sticky and shaped like sickles used to cut wheat. When these hard and pointed red cells go through the small blood tube, they clog the flow and break apart. This can cause pain, damage and a low blood count, or anemia. What is sickle cell trait? A person with the sickle cell trait does not have (and will never have) sickle cell disease. However, the presence of the trait may impact his/her children How do you get sickle cell disease? Sickle cell disease is not contagious; you cannot "catch" it. You inherit it from your parents. If, for example, one parent has normal hemoglobin ( type AA) and the second parent has abnormal hemoglobin ( type AS, or the sickle cell "trait"), there is a 50% chance that each child will have the sickle cell trait, but they will not have sickle cell disease ( type SS). The three most common forms of the disease in the United States are: 1. Hemoglobin...
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...exact number of people in any country with anemia is difficult to determine because the disorder often goes undiagnosed. According to the National Heart, Lung, and Blood Institute (NHLBI), anemia affects more than 3 million Americans. Other sources estimate that 4% of men and 8% of women in the general populations of Canada, the United States, and Western Europe have mild anemia. It is thought that the rates of anemia are 2-5 times higher in the developing countries. According to the World Health Organization (WHO), iron deficiency is the most important nutritional disorder in the world. WHO, estimates that 80% of the world's population may be iron deficient. The prevalence of vitamin B12 deficiency among the geriatric population is estimated at 5-15%. Although the prevalence of anemia is greater in women than men aged less than 75, by age 75, male prevalence surpasses female prevalence by about 5%. Anemia can be mild, moderate, or severe enough to lead to life-threatening complications. More than 400 different types of anemia have been identified, many of which are rare. Iron deficiency anemia The onset of iron deficiency anemia is gradual and, at first, there may not be any symptoms. The deficiency begins when the body loses more iron than it derives from food and other sources. Because depleted iron stores cannot meet the red blood cell's needs, fewer red blood cells develop. In this early stage of anemia, the red blood cells look normal but they are reduced in number...
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...technology because of two reasons: (1) the mouse is the most genetically manipulated mammal in the world and (2) it shares much of its genetic material with humans (and other mammals) which means that experimental findings in mice will often be directly relevant to conditions in humans. The paper focuses on the controversies and challenges in Gene Knockout Technology – an article/blog entitled “Sickle Cell Disease cured by Gene Knock-out”. Switching off a single gene can help treat sickle cell disease or sickle cell anemia (a chronic, usually fatal anemia marked by sickle-shaped red blood cells, occurring almost exclusively in Black people of Africa or of African descent, and characterized by episodic pain in the joints, fever, leg ulcers, and jaundice. The disease occurs in individuals who are homozygous for a mutant hemoglobin gene) by keeping the blood forever young. The illness is caused by a mutant form of adult haemoglobin, but not by fetal haemoglobin. Targeting BCL11A, the gene responsible for the body's switch-over from fetal to adult haemoglobin, effectively eliminates the condition in mice. The mutant form of adult haemoglobin forms long sticky chains inside red blood cells. The cells containing these chains can clog small blood...
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...Stem cell research is an extremely diverse subject. There are people who agree with it, and other’s who do not. Some people do not believe in it because of their religious beliefs, which is understandable. What they do not know though is how many diseases it can cure or how many lives it could save. The only type of stem cell research that is right is adult stem cell research, which is what we will be discussing in this paper. In no way shape or form is it right for someone to use embryonic stem cells. The only way that it is okay to use them is if you have already had a child and take them from the umbilical cord. But one should never abort a child just for something such as stem cells. Carry that baby full term and then use the cord to get...
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...1 Personal Impact Paper on Sickle Cell Disease Glenda Kessen NUR427 9/8/14 Amy Highland 2 Sickles Cell Anemia is a chronic, serious red blood cell disorder that is lifelong. "It is the most common genetic disease in the United States." (Guyatt, GH 2007). Sickle Cell Disease (SCD) is inherited and results in a decrease of the ability of red blood cells to carry much-needed oxygen through the body. The cells become clogged, due to their crescent shape, which keeps them from delivering oxygen. This can cause unbearable pain, damage to the body organs, and even death. The frequency of the pain episodes can range from several a year to multiple times a day. SCD is caused by hemoglobin S, which is an abnormal type of hemoglobin. When the cells are exposed to low oxygen levels, the Hemoglobin S changes the shape of the red blood cells. Red blood cells are made of marrow that is located inside the large bones of the body. The bone marrow is constantly making new red blood cells to replace the old cells. The life of the normal red blood cell life is about 120 days. Their purpose is to carry oxygen and remove the carbon dioxide, which is a waste product, from the body. Sickle-shaped cells die about ten to twenty days that prevents the bone marrow from making new red blood cells. Ethnicity plays a part in SCD, with African Americans more likely to be affected. Both parents are carriers of the sickle cell trait which is passed on to the child. The child will inherit...
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...whether or not a person may carry a higher risk for some diseases may in fact save their life, or the lives of their current or future children. However, over the years of development of the science, more and more controversial types of testing have developed. In this paper, the science of genetic testing will be introduced by going through a brief history, the different types of genetic testing available, as well as the controversies that surround them. History Genetic testing had a very positive and productive start. The first usage of Genetic Testing occurred over half a century ago, beginning with the testing of infants for PKU, or Phenylketonuria, “an inborn error of metabolism in which an amino acid buildup in the blood causes mental retardation.” (Lewis) To test infants, a drop of blood was taken from their heel while at the hospital after birth. If a child was found positive for PKU, dietary treatment was used to prevent loss of brain function. Testing was reliable and results were accurate. The disease being tested for was easily treatable, and every child that came through was tested without a problem. (Lewis) In the 1970’s, doctors began the process of testing individuals for sickle cell anemia and Tay-Sachs disease. The testing for these two diseases became mandatory in twelve states. However, because of the small amount of information available to the general public, misunderstanding of test results became common. Another factor for disappointment at the...
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...Stem Cell Research Paper Stem Cell Research Paper Human Biology The human body is capable of many miraculous feats. Every hour, every minute, every second, millions of cells are working to maintain homeostasis within the body. This paper is going to focus on one type of cell in particular, the stem cell. The properties of this little cell are amazing. These unique cells self-regenerate through cell division, and in addition to being unspecialized, have the ability to develop into many different specialized cells of the body. Numerous studies have shown the potential of stem cells to cure cancers, as well as slow or reverse the damages of some neurological disorders, yet stem cell researchers have met with both public and legal resistance during their attempts to show the incredible usefulness of these cells. Therefore, the question is, with stem cell research showing the potential to reverse the damage from or slow the progression of neurological disorders, and possible cures for cancer and other diseases and disorders are the possible benefits too much to ignore? The ability to self-regenerate is one the things that makes the stem cell such an appealing area to study. Most cells and organs in the body do not have the ability to self-regenerate, nor self-repair but stem cells can do both. Stem cells themselves are unspecialized, in that they have so special function (Stem Cell Basics, 2009). Part of the beauty of the stem cell is that through cellular...
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...doctors when prescribing drugs for Iron Deficiency anemia Research paper presented to SPPSPTM, NMIMS In partial fulfillment of the Requirement for the Degree B.Pharm + MBA (MBA PharmaTech) By Dishali Shah A073 Academic Year 2015 - 2016 Statement by candidate This is to submit that this submission report is my report entitled “Prescription behavior of doctors when prescribing drugs for Iron Deficiency anemia” represents my ideas in my own words and where others’ ideas have been included, I have adequately cited and referenced the original sources. I also declare that I have followed all the principles of academic honesty and integrity and have not misrepresented or fabricated or falsified any idea/ data/ fact / source in my submission. I understand that any violation of the above will be a cause of strict disciplinary action by the School and can also evoke penal action from the sources, which have thus not been properly cited, or from whom proper permission has not been taken when needed. P. Score________% Signature of Student Name of Student SVKM’s NMIMS Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, Vile Parle (W), Mumbai-400056. SHOBHABEN PRATAPBHAI PATEL SCHOOL OF PHARMACY AND TECHNOLOGY MANAGEMENT, SVKM’s NMIMS 2 Certificate The work described in this report entitled “Prescription behavior of doctors when prescribing drugs for Iron Deficiency anemia” has been carried out by Ms. Dishali J. Shah under...
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...experiments in this paper done through instruction in graduate course: Biotechnology laboratory in the natural sciences and mathematics department at the university of texas at dallas, RICHARDSON, TX 75080 march 2016 [Company name] | [Company address] ------------------------------------------------- γ-globin analysis by expression profiling through RT-qPCR, quantification through ELISA, and oxidative stress management analysis by FACS from KU812F cells under treatment by δ aminolevulinic acid, succinylacetone, and N-methyl mesoporphyrin Shaan Sarode, Jose Cordero, and Dr. Li Liu experiments in this paper done through instruction in graduate course: Biotechnology laboratory in the natural sciences and mathematics department at the university of texas at dallas, RICHARDSON, TX 75080 march 2016 [Company name] | [Company address] ------------------------------------------------- γ-globin analysis by expression profiling through RT-qPCR, quantification through ELISA, and oxidative stress management analysis by FACS from KU812F cells under treatment by δ aminolevulinic acid, succinylacetone, and N-methyl mesoporphyrin Shaan Sarode, Jose Cordero, and Dr. Li Liu ABSTRACT Hemoglobinopathies refer to a group of blood related disorders that encompass important disease such as thalassemia and sickle cell disease. Because many of these disease are hereditary more aggressive genetic therapies are showing promise as possible avenues of treatment. One such method is to re-express...
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