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Sickle Cell Disease

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A Report on Sickle Cell Disease Name: Professor:
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Sickle Cell Disease Sickle cell disease is a life threatening illness passed down from parents to children through the genes (Piel & Weatherall, 2015). The disease therefore, is present at birth but the signs come to the fore after the fourth month. The disease has been recognized as a major public health concern by international agencies and is common among many people in Africa, the Arabian Gulf, Turkey, India; the Mediterranean and their descendants spread around the world. For instance, in United States one in 400 African-American infants is born with sickle cell disease annually (Ibid).

Description of Sickle Cell Disease Sickle cell disease comprises of red blood cell disorders whose main feature is abnormal hemoglobin in the red blood cells. Hemoglobin is an oxygen carrying protein in the red blood cells (Peterson, 2008). The abnormality of the hemoglobin is caused by a mutation in a gene of the hemoglobin protein. This abnormality hinders the proper formation globin genes of the hemoglobin molecules resulting in abnormal hemoglobin that may take the forms of “S” hemoglobin or “SC” hemoglobin or “beta-thalassemia” hemoglobin as noted by (Rees, Williams & Gladwin, 2010).

Types of Sickle Cell Disease The disorders; sickle cell anemia disease (caused by “S” hemoglobin), “SC” disease (caused by “SC” hemoglobin and “S-beta thalassemia” (caused by “beta-thalassemia” hemoglobin) are collectively referred to as sickle cell disease (Rees et al, 2010). The most common form of Sickle cell disease is the Sickle cell anemia. Sickle beta-thalassemia is less common but can be either mild or severe while hemoglobin S-C disease is milder than Sickle cell anemia.

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