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Smallpox Vaccine Summary

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An important feature of the vaccine is that it can also provide retroactive protection against Smallpox if someone has been exposed up to three days after exposure providing immunity for three to five years after the shot (13-CDC Vaccination Fact Sheet). This vaccine is not recommended for individuals with any heart disease (including asymptomatic ones) because cardiac events were observed following vaccination in individuals with previous conditions (13-CDC Vaccination Fact Sheet). The vaccine is also not advised for pregnant women or women who plan to become pregnant within a month, as the vaccine can cause the fetus to contract the virus, leading to stillbirth (13-CDC Vaccination Fact Sheet).
Though worldwide, vaccination is not practiced, …show more content…
But beyond the vaccine, the drug pipeline has recently produced some promising treatments, none of which are currently FDA approved. Cidofovir, a “nucleoside analog that inhibits viral DNA replication,” is currently approved to treat cytomegalovirus infections, but can cause kidney toxicity and many researchers are trying to create an alternative that would be more suitable for Smallpox (Mucker et al., 2013, lines 64-65). This has developed into research for Brincidofovir, an oral drug that would have fewer side effects (9-NIH). Brincindofovir is a DNA polymerase inhibitor that can act as a vehicle to deliver large amounts of Cidofovir to the target …show more content…
This will, of course, decrease with each generation that remains unvaccinated. Given the highly infectious nature of the disease and the success of the vaccine, it seems ill advised to not vaccinate all individuals today. If an outbreak of natural or terrorist origins were to occur, the possibility of vaccinating everyone within 3-5 days seems unlikely at best and Smallpox is a disease where caution necessitates a theoretically unnecessary vaccine. Given the potential for accidents (such as the one that happened in Britain), the issue of bioterrorism possibilities, and the low numbers of viral shed needed to spread disease, it seems imprudent if not dangerous to not proactively protect

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