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Specific Aims Essay

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A. Hypothesis and Specific Aims In many debilitating conditions produced by structural brain injuries such as diffuse axonal injury, stroke, neurodegenerative disease, as well as functional disorders such as depression, objective measures of activity are crucial to assess disease severity, and consequently management and outcome assessment. Recent advances in miniaturization – specifically, the availability of compact and inexpensive accelerometers and gyroscopes – opens up the possibility of making such measurements over extended periods of time, and outside the confines of a laboratory. This approach is especially essential in severe brain injury, where there are limited treatments to enhance motor recovery and the natural history is poorly understood.

Specific Aim 1 is to automate the determination of type and quality of upper body movements made by subjects recovering from severe brain injury. We will record movements of subjects recovering from severe brain injury using video and functional activity monitors (FAMs; accelerometer-gyroscopes; Wagenaar et al., 2011) over two-to-three-day research hospital admissions. We will also record healthy controls with video and FAMs while they mimic the most common movements of the clinical subjects. 1A) We will …show more content…
For example, work performed during the PI’s CTSC KL2 award revealed that brain activity (measured by electroencephalography; EEG) in an MCS patient fluctuated between time periods when the subject could perform goal-directed movements versus times when they were not able (Figure 2). This analysis required hours of detailed annotation of video data. The outcomes of this proposed work would allow for automated detection of these fluctuations in motor performance, greatly decreasing the time required for

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