Premium Essay

Synthesis of Acetanilide & Purification by Recrystallization

In: Science

Submitted By soundsource
Words 1798
Pages 8
Synthesis of Acetanilide and Purification by Recrystallization
Par, B., Ramos, S., Reynaldo, H., Roque, P., Servidad, Y., and Soriente, P.
2D-Pharmacy, Group No. 7, Department of Pharmacy, Faculty of Pharmacy, University of Santo Tomas, España Boulevard, 1015 Manila, Philippines

Abstract Recrystallization is the primary method of purification used to isolate organic compounds in a supersaturated solution by the difference of solubility at different temperature that results to the separation of the compound from the solution. The purpose of this experiment is to synthesize acetanilide by the acetylation of aniline and to obtain pure acetanilide by purification of the collected crude acetanilide by crystallization. The recrystallizing solvent was chosen among ethanol, water and hexane. The acetanilide was synthesized and formed by acetylation of aniline and acetic anhydride, and it was then cooled to hasten the formation of crystals. After cooling, the mixture was filtered and dried to obtain the crude acetanilide. The crude acetanilide and the chosen recrystallizing solvent was mixed and heated in the water bath until the solid dissolved. The solution was filtered while hot and its filtrate was cooled in an ice bath. The filtrate was then filtered to collect the crystal residue formed. The crystals were washed with distilled water and allowed to dry to obtain the pure acetanilide. The weight of pure acetanilide was measured and the melting point of the pure acetanilide was determined. Based on the results obtained, water is the best recrystallizing solvent among the three given solvents and the limiting reagent in synthesis of acetanilide is aniline.


Purification of a solid by recrystallization from a solvent depends on the fact that different substances are soluble to different solvents. The impurities are much more...

Similar Documents

Free Essay

Recrystallization of Acetanilide

...Laboratory Recrystallization of Acetanilide Experiment 4 Author: Janina Erika G. Sese Group 8 – 2C Medical Technology (A.Y. 2015-2016) Members: Kathleen Danielle Marie A. Robles, Amiel C. Sabangan, Hanz Jefry A. Saliendra, Andrea Betina M. Vega, Anna Denise Z. Yang ------------------------------------------------- Date Submitted: October 28, 2015 ------------------------------------------------- ABSTRACT Recrystallization is the simplest and most widely used operation for purifying organic solids that differ in their solubility at different temperatures. In this experiment, three test tubes with water, hexane and, ethanol, respectively, were used to dissolve pure acetanilide. These test tubes were placed in a water bath for one to five minutes, then, were cooled through running water for the selection of the best solvent to use in recrystallization. Crude acetanilide was obtained by mixing two milliliters aniline and 20 milliliters distilled water with three milliliters acetic anhydride, which was cooled with running water. It was then filtered and dried for the procurement of crude acetanilide. This was mixed with 20 milliliters of the chosen solvent and heated through water bath until the solid was dissolved. Next, it was immediately filtered while hot. The filtrate was collected and was cooled with running water leading to the recrystallization of pure acetanilide. This was again filtered with a tared filter paper to obtain pure acetanilide. This pure......

Words: 2243 - Pages: 9