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The Pros And Cons Of Non-Inferiority Wealth

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Solid clinical acumen and statistical logic are needed in deciding the non-inferiority margin. These are two underlying perspectives, both of which have significant disadvantages. One way to establish the margin is based on a clinical understanding of a nominally relevant response. In this way, the non-inferiority margin should be the minimal clinically significant distinctness between treatments after taking into consideration the implication of the primary and secondary endpoints. But, this is apparently intuitive, and it is probable to set the margin larger than the effect of the active control, which could be detrimental (Snapinn SM, 2000). A clinically acknowledged criterion for non-inferiority margin is a corresponding disparity of 15%

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