Kaposi sarcoma is a tumor cause by human herpes virus, also known as Kaposi sarcoma-associated herpes virus. It was originally described by Moritz Kaposi, a Hungarian dermatologist practicing at the University of Vienna in 1872. It became more widely known as one of the Aids-defining illnesses in the 1980s. The viral cause for this cancer was discovered in 1994. Although KS is now well-established to be caused by a viral infection, there is a widespread lack of awareness of this even among persons at risk for KSHV/HHV-8 infection. Kaposi’s sarcoma is a systemic disease that can present with cutaneous lesions with or without internal involvement. Four subtypes have been described: Classic KS, affecting middle aged men of Mediterranean and Jewish descent; African endemic KS; KS in iatrogenically immunosuppressed patients; and Aids-related K. The erythematous to violaceous cutaneous lesions seen in the KS have several morphologies; macular, patch, plaque, nodular, and exophytic. The cutaneous lesions can be solitary, localized or disseminated. KS can involve the oral cavity, lymph nodes, and viscera. Classic KS tends to be indolent, presenting with erythematous or violaceous patches on the lower extremities. African endemic KS and AIDS- related KS tend to be more aggressive. The Aids-related KS lesions often rapidly progress to plaques and nodules affecting the upper trunk, face, and oral mucosa. The diagnosis can be made with a tissue biopsy and, if clinically indicated, internal imaging should be done. Once the diagnosis of KS has been made, treatment is based on the subtype and presence of localized versus systemic disease. Localized cutaneous disease can be treated with cry therapy, or surgical excision. Extensive cutaneous disease and/or internal disease may require iv chemotherapy and immunotherapy. Discontinuation or reduction of immunosuppressive therapy is