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What Is Deafferentation?

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Several proposals have been made regarding the mechanisms of cause of CBS. Of these theories, the deafferentation theory and the corticol release phenomenon are most popular (Yacoub & Ferrucci, 2011). Deafferentation occurs when the destruction or injury to sensory nerve fibers causes an elimination or interruption of action potential propagation along an afferent nerve pathway. The areas of the brain that have lost sensory stimulation due to deafferentation may experience hyperexcitability. Hyperexcitability is caused by one or a combination of increased neurotransmitters in the presynaptic region of neurons, or increased receptors on the postsynaptic membrane resulting from prolonged inactivity (Yacoub & Ferrucci, 2011). This also leads to

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