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Wound Healing Process

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Wound healing is a normal biological response to a tissue injury in human body. This injury can be acute or chronic. It takes place in many cell types (endothelial and epithelial cells, lymphocytes, fibroblasts, etc). Normal healing is the interaction of a complex cascade of cellular events that generates to restore and repair the tensile strength of damage tissue (Guo and DiPietro, 2010).The wound healing process differs with young adults and elderly people. In elders the wound healing process are impaired and the rate of wound healing is slightly reduced. The injuries of wound healing in elders are chronic disabling condition (Thomas, 2001).
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Wound healing process can be divided into 4 distinct phases such as hemostasis, inflammation, …show more content…
In the initial stage of tissue injury the ATP molecules are released and collagens are exposed on walls of blood vessel. Blood clot is formed and acts as a temporary barrier to prevent excess bleeding and limits the spread of pathogens into the blood. In Primary hemostasis platelets attach to collagen fibers found in the damaged endothelium using specific collagen receptor glycoprotein’s (GPIb/IX/V) to form the primary hemostatic plug (Figure 2) (Reinke and Sorg,2012). Figure 2: Primary hemostasis (Hackner and White,2016)
After the fracture of the epithelial wall on the blood vessel the platelets attach to sub-endothelial surface to rapidly regulate high-affinity platelet integrin and mediate platelet aggregation. Once platelet binds, they stimulate local activation of plasma coagulation factors triggering the fibrin clot. Exposure of blood plasma to tissue factor, produced by sub-endothelial cells, initiates an accelerated cascade of activated proteins that leads to fibrin formation. The conversion of fibrinogen to fibrin and its polymerization and cross linking forms a twisted gelatin-like platelet plug, producing a stable clot. Platelet activation also releases many signalling molecules from their cytoplasmic granules. Inflammatory cells are stored …show more content…
This new stroma begins to penetrate the wound space near four days after injury. The new blood vessels facilitate the entry into the wound on cells such as macrophages and fibroblasts. Macrophages provide growth factors that stimulate further angiogenesis and fibroplasia. Both PDGF and TGF-β stimulate fibroblast differentiation to produce base substance and collagen. Fibroblasts are the key players in the synthesis, deposition and remodelling of the extracellular matrix, which gives the wound strength and substance (Radek et al, 2005).
Maturation phase
The maturation phase usually begins 3 weeks after injury. This phase is characterized by the transition from granulation tissue to scar formation. Collagen deposition by fibroblasts continues for a prolonged period and gradually increases the tensile strength of the scar tissue The human wound reaches its maximal strength at one year, with a maximal tensile strength 80% of normal skin (Hess, 2008).
Global differences in wound healing between young and old

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