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Psychoactive Drugs and Their Effects

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Psychoactive Drugs And Their Effects Abstract
This paper discusses three different psychoactive drugs, one from each classification, and their general psychological and physical effects. Cocaine, a stimulant, Cannabis, a hallucinogen and Oxycodone, a depressant will be covered. Positive, neutral and adverse effects will be discussed as well as long-term use and withdrawal symptoms. Cannabis has a section regarding its medicinal use in society. Cocaine is a naturally derived central nervous system (CNS) stimulant and topical anesthetic that is extracted and refined from the Erythroxylum coca plant, which is grown primarily in the Andean region of South America. Coca leaf chewing has been around for thousands of years. The drug was first isolated in the 1850’s and had medicinal use through the late 19th century. Recreational use became a problem in the early 20th century and became illegal is the United States in 1914. The chemical name for cocaine is benzoylmethyl ecgonine; it is a bitter, white, odorless crystalline drug. Cocaine has multiple methods of ingestion; it can be insufflated, taken orally or intravenously. It can be smoked to some degree, but tends to burn rather than vaporize because of the high temperature required. Freebase cocaine vaporizes at smoking temperatures and creates a more intense high whilst using less product. Street terminology consists of coke, snow, nose candy, white, blow and soft, among others. Freebase is known as crack, rock and hard, among others.
Cocaine interferes with the reabsorption of dopamine, norepinephrine and serotonin. The buildup of these neurotransmitters in the brain create the high the user seeks. The general effects of using the drug are feelings of well-being/euphoria, stimulation, sexual arousal, increased focus, alertness, wakefulness, talkativeness, athletic performance, energy, decreased fatigue and appetite. Physical effects include increased heart rate, blood pressure, speed of respiration and body temperature. The user may also experience agitation, anxiety, paranoia, dizziness, nausea, vomiting, hostility/violent behavior, dilated pupils, insomnia, irritability and restlessness. In some cases it has caused kidney failure, seizures, strokes and heart attacks. High doses may make the individual show patterns of psychosis with confused and disorganized behavior, fear, hallucinations or being extremely antisocial. Overdosing on cocaine can cause hallucinations, convulsions, hyperthermia, stroke, heart attack and possible death. People with latent congenital heart defects, epilepsy, high blood pressure or thyroid problems are at a higher risk of life-threatening complications. Long-term use is known to cause restlessness, anxiety, hyperexcitability, paranoia, irritability, insomnia, weight loss, malnourishment, and a variety of other psychological symptoms. Insufflating over extended periods of time can lead to damage of nasal cartilage and mucosa, eventually leading to a hole in the septum. Intravenous long-term use can result in life-threatening infections and allergic reactions, as well as blood diseases like HIV and Hepatitis C from sharing needles.
The onset depends of which method was used to ingest the drug. Typically, insufflation is within one minute, intravenous is a few seconds, while smoking freebase is almost instantaneous. The duration is normally 20-40 minutes for insufflation and 5-15 minutes for smoking or intravenous. As the high wears off, the user is inclined to consume more of the drug, which results in a quick route for addiction. Coke has very addictive qualities, although it is not believed to be physically addicting. There are many studies that show it is psychologically addicting, with some showing that it actually rewires the way the brain operates. Initial tolerance develops quickly, but appears to level off relatively quickly as well. Withdrawal symptoms include cravings for the drug, hunger, irritability, apathy, depression, paranoia, suicidal ideation, loss of sex drive, insomnia or excessive sleep, dizziness, shaking and/or feeling cold. (Erowid, 1998)
Tetrahydrocannabinol (THC) is the main psychoactive ingredient in the Cannabis plant, which is part of the Cannabaceae family. There are three species of Cannabis; sativa, indica and ruderalis. The three species are usually interbred for recreational use, but the most common varietals are sativa and indica. Cannabis is a fast growing bushy annual with dense, sticky flowers that produce THC. It is the most widely used illegal drug and has a long history of medicinal, recreational and industrial use. The fibrous stalks of the plant are utilized to create clothing and rope, among other consumer goods. Cannabis has been used medicinally and recreationally for thousands of years, it found its way to America in the middle of the 19th century before being outlawed in 1937. The plant grows wild in many tropic and temperate climates, but is mainly cultivated indoors and outdoors for its flowering tops (buds), which are dried before they are smoked or eaten. THC comes in different forms, ranging from a concentrated resin called hashish, to a sticky liquid called hash oil as well as synthetically made THC pills for medicinal use. The active ingredients in Cannabis are called cannabinoids, which the plant produces many. Cannabinol, cannabidiol, cannabinolidic acid, cannabigerol, cannabichromene and tetrahydrocannabinol are all found in the plant, but the latter is considered responsible for most of the psychoactive effects. The drug is federally illegal, although 19 states have either legalized medicinal use, decriminalization of personal amounts , or both. Two states have legalized the recreational use of the drug for adults over the age of 21 (Wikipedia, 2013). Common names include marijuana, pot, weed, grass, kush, Mary Jane, green, dope and ganja.
Positive effects of using include mood lift, euphoria, relaxation, stress reduction, changes in perception, enhancement of senses (smell, taste, touch, hearing, vision), changes in thought and expression, talkativeness, giggling, pain relief, reduced nausea, increased appetite, increase in body and mind connection. It also creates an increase in appreciation, awareness and the emotional impact of music, along with a deeper connection to songs. Ideas tend to flow more easily; allowing for creative, philosophical, abstract or deep thinking. Some neutral effects include a general change in consciousness, tiredness, sleepiness, lethargy, blood-shot eyes, mouth dryness, sticky-mouth, interruption of linear memory, racing thoughts and an altered sense of time. Adverse effects include paranoia, dry mouth, respiratory problems and nervousness/racing heart, reduced ability to concentrate, impaired memory, tiredness, confusion, coughing, asthma, upper respiratory problems, dizziness, headaches, clumsiness, loss of coordination, increased heart rate, agitation, feeling tense, mild to severe anxiety leading to possible panic attacks, nausea (especially when combined with alcohol, some pharmaceuticals or other psychoactive drugs). There have been zero confirmed deaths of cannabis only poisoning. Long-term use can result in excess coughing, increased frequency of lung and throat infections and reduced lung capacity. Those individuals with schizophrenia, paranoia or symptoms of psychosis should avoid the use of cannabis, as with any other drug, can contribute to worsening symptoms and a decline in normal functioning. “Hangover” or day after symptoms include dry mouth, joint stiffness, irritated eyes, fatigue, drowsiness, foggy/slow thinking, reduced memory skills and slower speed of recall. (Erowid, n.d.)
The onset of smoked cannabis is immediate but if eaten, takes 1-2 hours depending of contents of stomach. The duration of smoking lasts approximately 1-2 hours while oral ingestion lasts 3-5 hours. There is a psychological habituation for some people with this drug. Most users do not experience signs of physical addiction but with regular daily use there can be mild to medium withdrawal symptoms that can occur for as little as a few days, but could last up to 6 weeks. These include anhedonia, headaches, discomfort, difficulty sleeping, desire to smoke cannabis, loss of appetite, increased boredom, fatigue, lethargy, slow thinking and talking.
Cannabis has many possible medical uses, many of which are currently being researched. It is known to help with symptom relief of cancer, AIDS wasting syndrome and glaucoma. The appetite stimulating and anti-nausea properties can help counteract the drastic weight loss and weakness associated with wasting syndrome as well as the nausea related to cancer chemotherapy treatments, and helps them regain weight. It helps glaucoma patients by reducing ocular pressure, which has the possibility of causing damage to the eye. There are even some medical research companies that have dedicated their mission to using cannabis and its extracts to fight deadly diseases. A Denver-based corporation named Cannabis Science, Inc. is conducting innovative research, developing novel cannabinoid-based therapies for the treatment of cancer and infectious diseases, such as HIV. The Company works with leading experts in drug development, medicinal characterization, and clinical research to develop, produce, and commercialize phytocannabinoid-based therapies (Cannabis Science Inc, 2013). This corporation has had some amazing preliminary results from some patients who have chosen to self-medicate with their products. (Cannabis Science Inc, 2012) (Cannabis Science Inc, 2012)
Oxycodone is a semi-synthetic opioid analgesic used primarily in treatment of pain and is very similar to codeine and morphine in chemical structure. First synthesized in Germany in 1916, it became available in the United States around 1939. It was placed on the Schedule II list in 1970, then OxyContin was produced in 1995 and quickly gained popularity, resulting in a significant increase in recreational use. There are several different types of this drug available; Percocet, which contains acetaminophen, Percodan, which contains aspirin and OxyContin, which is oxycodone in a time-release version. Oxycodone is most effective in treating acute pain rather than chronic pain. The precise pharmacological mechanism is unknown but is believed to relate to the opiate receptors in the central nervous system.
Primary effects include analgesia, sedation, reduction of anxiety, euphoria and relaxation. Adverse effects from the common: nausea, vomiting, constipation, dizziness, headache, pruritus, dry mouth, sweating, fatigue and weakness; to the less common: impaired thinking, confusion, loss of appetite, nervousness, insomnia, fever, diarrhea, difficulty urinating, clammy skin, light-headedness and fainting; to the rare and possibly fatal: abdominal pain, seizures, convulsions, difficulty breathing, respiratory depression, respiratory arrest and circulatory depression or shock. Combining oxycodone with alcohol or other depressants can result in fatal slowing in the CNS and respiratory system. The drug is notoriously addictive, both psychologically and physically, especially with daily use. Tolerance develops rather quickly, over a period of weeks, which results in higher doses being needed to attain the same effects. Withdrawal symptoms include aches and pains, restlessness, nausea, anxiety, diarrhea, fever, headaches, runny nose, tremors, sweating, vomiting and trouble sleeping. (Erowid, n.d.)

References

Cannabis Science Inc. (2012, February 23). Cannabis Science Presents Newest Case Photos of the 3rd Critical Squamous Cell Carcinoma Self-Medicated Cannabis Patient with Clear Continued Improvement. Retrieved from Cannabis Science Inc: http://www.cannabisscience.com/index.php/news-media/news-releases/239-cannabis-science-presents-newest-case-photos-of-the-3rd-critical-squamous-cell-carcinoma-self-medicated-cannabis-patient-with-clear-continued-improvement
Cannabis Science Inc. (2012, July 30). Cannabis Science Releases New Photos on the Continual Improvement of Patient Three Who Suffers from Squamous Cell Carcinoma. Retrieved from Cannabis Science Inc: http://www.cannabisscience.com/index.php/news-media/news-releases/276-cannabis-science-releases-new-photos-on-the-continual-improvement-of-patient-three-who-suffers-from-squamous-cell-carcinoma
Cannabis Science Inc. (2012, January 24). Cannabis Science Updates Latest Remarkable Follow Up Photographs Received from 3rd Cancer Patient. Retrieved from Cannabis Science Inc: http://www.cannabisscience.com/index.php/news-media/news-releases/229-cannabis-science-updates-latest-remarkable-follow-up-photographs-received-from-3rd-cancer-patient
Cannabis Science Inc. (2013). Corporate Overview: Cannabis Science. Retrieved from Cannabis Science Inc: http://www.cannabisscience.com/index.php/our-company/overview
Erowid. (1998, July 26). Cocaine: Erowid. Retrieved from Erowid: http://www.erowid.org/chemicals/cocaine/cocaine.shtml
Erowid. (n.d.). Cannabis: Erowid. Retrieved from Erowid: http://www.erowid.org/plants/cannabis/cannabis.shtml
Erowid. (n.d.). Oxycodone: Erowid. Retrieved from Erowid: http://www.erowid.org/pharms/oxycodone/oxycodone.shtml
Wikipedia. (2013, December). Medical cannabis in the United States: Wikipedia. Retrieved from Wikipedia: http://en.wikipedia.org/wiki/Medical_cannabis_in_the_United_States

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