...Times March,2015 A Breakthrough Treatment for Lung Cancer Approved What you need to know about this promising new drug On March 5, a novel way to treat lung cancer won approval from the Food and Drug Administration (FDA). The latest drug, Opdivo, has showed promise with other cancers, and is the first to use the immune system to tackle hard-to-treat lung tumors. Here’s what you need to know. How does the drug work? Opdivo (nivolumab), made by Bristol-Myers Squibb, works the same way that releasing a parking brake frees a car to move. Normally, the immune system is held back from recognizing tumors as foreign and potentially harmful, since tumors are the body’s own cells that grow abnormally. Without such checks, “the immune system will destroy you,” says Dr. James Allison, chair of immunology at MD Anderson Cancer Center who discovered the first such brake that protected cancer cells from the immune system. But nivolumab releases this check on the immune system’s normally voracious appetite for anything it doesn’t recognize, so the body’s own defenses can preferentially recognize tumor cells as targets. In the study submitted by the company to the FDA, 15% of patientsshowed some shrinkage or complete disappearance of their tumors. What makes this drug different from other cancer treatments? Unlike surgery, chemotherapy, radiation or the anti-cancer drugs that interrupt specific signals that tumor cells use to survive, nivolumab doesn’t target the tumor itself. Rather it...
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...a project cancer and dna oncology information system with numerous illustrations oη by okeke chika tochukwu Department of computer science madonna unversity, elele campus ©august, 2012 TABLE OF CONTENTS declaration ��������������������������������������������������������������������������������������������� i dedication ������������������������������������������������������������������������������������������������ ii acKnoWledgement ���������������������������������������������������������������������������� iii aBstract ��������������������������������������������������������������������������������������������������� iv CHAPTER ONE �������������������������������������������������������� 1 introdUction �������������������������������������������������������������������������������� 1 BackGround oF study ���������������������������������������������������������������������������������������������������������������������1 oBJectives oF study ��������������������������������������������������������������������������������������������������������������������������1 scope oF the study ���������������������������������������������������������������������������������������������������������������������������2 JustiFication oF study ��������������������������������������������������������������������������������������������������������������������2 statement oF proBlem �������������������������������������������������������������������������������������������������������������������3...
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...NHPA | Summary | Why selected (all selected for similar reasons; finical impact on health care system) | Determinants as risk factors | Health promotion Program | CardiovascularHealth | Refers to maintaining healthy functioning of the heart and blood vessels. CVD encompasses all diseases and conditions of the heart and blood vessels (including coronary heart disease, stroke and peripheral vascular disease) caused mainly by blood supply to the heart, brain and legs. | -To improve cardiovascular health by reducing CVD.-CVD is leading cause of premature death and second leading cause of burden of disease.- CVD is also largely preventable and places a large economic burden on the health care system. | 1. biological: cholesterol levels, age, sex and genetics. high blood pressure-indicates that the heart is already working harder and under pressure, which can lead to stroke and kidney disease.Body weight- excess body weight places greater strain on heart and increases hypertension and cholesterol levels.2. Behavioural: physical activity, tobacco smoking poor nutrition-diets high in saturated fat such as cholesterol can contribute to overweight and obesity. Low intake of fruit and vegetables can contribute to increased snacking on high fat and high sugar foods, increasing obesity, which heightens risk of CVD.Physical enviro: air quality (tobacco smoke) Access to recreational facilities-if lacking access, they might not exercise as much as otherwise might. Heightens risk of CVD...
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...to Identify and Resolve Conflict ……………………………………………………..10 8.0 Change Management Plan …………………………………………………………………11 9.0 Resource Utilization Plan ………………………………………………………………….11 10.0 Reference Page …………………………………………………………………………….12 Introduction: We found pharmaceutical companies to be better fit for our project. This industry touches each person on this planet in one form or another and the work they are conducting in search of making every ones live healthier and live longer than our fore fathers. When we stacked up all pharmaceutical companies, we found Merck Corporation to meet all of the criteria that we were looking for in a pharmaceutical industry. Merck have conducted many projects concurrently during drug developments and clinical studies for those drugs to reach the market and save lives while they accomplish their financial objectives. Merck Corporation have been serving people for over 350 years with a clear mission insight that their primary focus entrepreneurial starts with people and their culture is based on mutual respect and strong sense of identification. Jacob Merck purchased Angel...
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...very similar with 1) beatable revenue growth expectations (2014e: +16% vs. 2012/2013: +12%) including several high-profile drug launches, 2) many pivotal studies set to read out and 3) a stable/favorable regulatory and reimbursement environment. Notably, these factors should continue to make biotech attractive to generalist investors, who played a major role in the 2013 outperformance. Our bias is to stick with large caps as well as mid-caps with approved products; revenue/EPS/cash flow forecasts for 2015 and beyond look broadly beatable, in our view. In contrast, we suspect that “pure pipeline” or tech platform small caps could be more volatile in 2014. We continue to believe that the biotech industry is in the early innings of an innovation cycle with many labelexpansion opportunities and novel agents in phase 2 or 3 trials that are largely unaccounted for in Street models. Hence, we are bullish on the group for 2014. Please join us for a call today at 11am ET to discuss our sector outlook/favorite names (US dial-in: 888-889-1309; OUS: 773-756-0161; Passcode: BIOTECH). Large-cap biotech: We don’t believe that a strict assessment of P/E multiples accurately addresses the nuances of the sector (2014e – Biotech: 22x vs. S&P 500: 15x). In our view, large caps are poised for an inflection point in revenue growth over the next two years, driven by significant drug launches in major therapeutic categories. Some of these include Gilead’s Sovaldi in hep C, Biogen’s...
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...San Diego County Community Health Rhonda Mohler Western Governors University Community Health and Population Focused Nursing C228 Marc Gayol June 30, 2014 San Diego County Community Health San Diego California shares a border with Mexico and has an estimated population of 3,211,252. It is a diverse and multicultural population comprised of 32.7% Hispanics, 47.6% Whites, 11.6% Asians, and 5.6% are Blacks (State & County QuickFacts, n.d.). San Diego has a long history with the US Military; it has six Bases and one US Coast Guard Station ("San Diego Military Bases," n.d.). San Diego is the second largest city in California, is rapidly growing, and is known for its temperate year-round climate and sandy beaches. It has many parks with open space, lakes and reservoirs, recreation activities, senior citizens services, and community safety services. San Diego also has multiple public services, excellent public schools, state of the art hospitals and clinics, and public transportation which include trains and trolleys (Community Services, n.d.). Sam Diegans can go to a museum, an opera, and attend an NFL game all in the same day. San Diego is an amazing place to live and has a lot to offer its citizens, but steps need to be taken to identify and evaluate disease in the community in order to promote optimal health and ensure the well-being of all San Diegans. Epidemiology is the study of disease in the community and then evaluating the reasons why the disease or condition...
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...NUR160 Ca Name: Jodi Wiak | Section: 160 | Instructor: Ms. Higgins | Dates of care: 4/1/14 | Week: 1st clinical | Name: Jodi Wiak | Section: 160 | Instructor: Ms. Higgins | Dates of care: 4/1/14 | Week: 1st clinical | General Survey | Age: 85 | Sex: F | Ethnicity: Caucasion | # of days since admission: 7d | Allergies: Latex PCN | Code Status: FULL CODE | Diet: TPN | Rationale: Small bowel obstruction and resection benefit TPN over tube feedings is that all the nutrition is delivered at a cellular level making it immediately available for the body to utilize rather than making the body breakdown and absorb nutrients in the GI tract. It makes it easier on the digestive tract by giving the GI a chance to rest and heal without causing more harm. The patient also has to expend energy to breakdown foods/nutrition through the GI tract. Getting it TPN conserves the much needed energy the patient needs to heal their tissues and gain strength. | Activity: bedridden w/slight mobility with a walker | Rationale: Post surgical abdominal surgery, pt age, weakness, and recent foot surgery limiting her mobility. | Behavior/Affect: My pt was anxious when I first arrived due to her elevated B/P, N&V, and pain intolerance. By the end of shift my patient was very calm and communicative. | Isolation: | Yes | No | Culture: ⦵ | Source: ⦵ | Type of Isolation: ⦰ ⦵ | Height: 5’ 7.5” | Weight: 133 | BMI: 20.5 (BSA 1.71) | General Survey | Age: 85 | Sex:...
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...04/17/2011 ------------------------------------------------- Table of Contents Executive Summary…………………………………………………………………………………………………. Introduction………………………………………………………………………………………………………… Population and Health Status………………………………………………………………………………………………………………… Demographic characteristics of population Life Expectancy, mortality data, causes of death Health Status Availability of Health Services Health care Providers Issues related to access of Health Care Expenditures Health services Expenditure & Financing………………………………………………………………………… Roles of the government Macro environmental influences on the health care system Political Socioeconomic Cultural Technological/Other relevant influences Summary Bibliography Executive Summary Australians have among the highest life expectancy in the world, and most have ready access to comprehensive health care of a high standard. The primarily tax-funded health system achieves reasonably cost-effective health care and good health outcomes and generally enjoys public support. Australia has a federal form of government with fiscal and functional responsibilities divided between the Australian Government and the six States and two Territories. Australia is a generally prosperous country with gross domestic product (GDP) per capita close to the Organization for Economic Co-operation and Development (OECD) average. The population reached 20 million in 2004, is highly urbanized, with 66% living...
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... University of Chicago, Chicago, Illinois, United States of America Summary: Recent cancer studies emphasize that genetic and heritable epigenetic changes drive the evolutionary rate of cancer progression and drug resistance. We discuss the ways in which nonheritable aspects of cellular variability may significantly increase evolutionary rate. Nonheritable variability arises by stochastic fluctuations in cells and by physiological responses of cells to the environment. New approaches to drug design may be required to control nonheritable variability and the evolution of resistance to chemotherapy. Cancer progression is a series of evolutionary changes. Those changes include enhanced cellular proliferation, reduced cellular death by abrogating normal apoptotic mechanisms, greater invasiveness by increased expression of proteases, and improved colonizing ability to achieve metastasis [1]. In response to drug treatment, cancer cells often evolve resistance and continue to spread. Each evolutionary step typically proceeds by acquisition of genetic or heritable epigenetic changes in cells. When does the novel genetic change arise in an evolutionary step? By the current view, rare genetic variants arise before widespread phenotypic change. The idea is that a novel phenotype always comes from a novel genotype [2,3]. For example, rare resistant genetic variants may exist before drug treatment [4]. The drug selects those rare resistant variants, killing the other cancer...
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...Sign In (Create a Free Personal Account) | Subscribe Search Annals of Internal Medicine Advanced Search Register for Alerts Information for Authors Submit a Manuscript Home Current Issue All Issues Online First Collections In the Clinic Journal Club CME Audio & Video Authors 17 December 2013, Vol 159, No. 12> Advertisement Email Share Get Permissions Get Citation Figures Slideset (.ppt) PDF Reviews | 17 December 2013 Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer: An Updated Systematic Evidence Review for the U.S. Preventive Services Task Force FREE Stephen P. Fortmann, MD; Brittany U. Burda, MPH; Caitlyn A. Senger, MPH; Jennifer S. Lin, MD, MCR; and Evelyn P. Whitlock, MD, MPH [+] Article and Author Information See Also: Published Letter: Padayatty et al Published Letter: Dror et al Published Letter: Hemilä Published Letter: Bolland et al Published Letter: Fortmann et al Oral High-Dose Multivitamins and Minerals After Myocardial Infarction: A Randomized Trial Long-Term Multivitamin Supplementation and Cognitive Function in Men: A Randomized Trial Enough Is Enough: Stop Wasting Money on Vitamin and Mineral Supplements Ann Intern Med. 2013;159(12):824-834. doi:10.7326/0003-4819-159-12-20131217000729 Text Size: A Related Articles Filter By Topic > Vitamin, Mineral, and Multivitamin Supplements for the Primary Prevention of Cardiovascular Disease and...
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...tumour-derived epithelial cells (circulating tumour cells or CTCs) have been identified in peripheral blood from cancer patients and are probably the origin of intractable metastatic disease1–4. Although extremely rare, CTCs represent a potential alternative to invasive biopsies as a source of tumour tissue for the detection, characterization and monitoring of non-haematologic cancers5–8. The ability to identify, isolate, propagate and molecularly characterize CTC subpopulations could further the discovery of cancer stem cell biomarkers and expand the understanding of the biology of metastasis. Current strategies for isolating CTCs are limited to complex analytic approaches that generate very low yield and purity9. Here we describe the development of a unique microfluidic platform (the ‘CTC-chip’) capable of efficient and selective separation of viable CTCs from peripheral whole blood samples, mediated by the interaction of target CTCs with antibody (EpCAM)-coated microposts under precisely controlled laminar flow conditions, and without requisite pre-labelling or processing of samples. The CTC-chip successfully identified CTCs in the peripheral blood of patients with metastatic lung, prostate, pancreatic, breast and colon cancer in 115 of 116 (99%) samples, with a range of 5–1,281 CTCs per ml and approximately 50% purity. In addition, CTCs were isolated in 7/7 patients with early-stage prostate cancer. Given the high sensitivity and...
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...Athens Information Technology Master in Management of Business, Innovation & Technology (MBIT) Management Information Systems E-Health in Greece compared to EU/US and the impact of Big Data in healthcare Prepared by: Athina Klaoudatou Christos Panagiotou Abstract The aim of this report is to describe the eHealth market. The focus is the Greek business landscape, current trends in the market, industry growth, drivers, and restraints, the technologies and the players in various aspects of the field. Data are presented about the evolution of the market and there are descriptions of what Greek companies offer. Moreover implementation measures are presented, along with progress achieved with respect to national and regional eHealth solutions in EU and EEA Member States. Table of Contents 1. The National Health System 1 1.1. Organizational structure 1 1.2. Some facts & figures 1 2. What is eHealth, definitions, areas of application, benefits 5 2.1. What is eHealth 5 2.2. Forms of eHealth 5 2.3. Benefits of eHealth 6 3. eHealth framework in European Union countries 7 3.1. eHealth Action Plan 2012 - 2020 7 3.2. eHealth in the European Countries 8 4. Application of eHealth practices 10 4.1. Electronic Health records (EHR) 10 4.1.1. Examples of current EHR use 10 4.1.2. Electronic Health Record in Greece 12 4.1.3. Summing up 14 4.2. Interoperability 15 4.2.1. Defining Interoperability in Healthcare Systems 15 4.2...
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...implementation of such plans by 2007 at the latest. • Include effective information systems with standardized indicators and periodic monitoring and evaluation, with the aim of showing a reduction in the magnitude of avoidable blindness by 2010. • Mobilize resources for eliminating avoidable blindness. In turn, the WHO agrees to: • Maintain and strengthen the WHO’s collaboration with governments and all partners of the initiative. • Ensure coordination of the implementation of the VISION 2020 plan, by setting up a monitoring committee grouping all those involved, including national government representatives. • Provide support for strengthening national capability, especially through development of human resources, to coordinate, assess, and prevent avoidable blindness. • Document, from countries with successful blindness prevention programs, good practices and blindness prevention systems or models that could be applied in other developing countries. • Report to the Fifty-Ninth World Health Assembly on the progress of the Global Initiative. Canada signed on to this agreement, and for that it deserves applause. However,...
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...1 Occupational Health and Safety Issues of Police Officers in Canada, the United States and Europe: A Review Essay © Jennifer R. L. Parsons June, 2004 2 Introduction Police officers play a pivotal role in North American and European societies. They are involved in many aspects of North American and European life. Officers’ involvement ranges from general, daily, proactive patrol activities to specific criminal activities such as narcotic investigations. Because there is such a wide range of activities involved in police work, there are many health and safety issues surrounding policing as an occupation. Police officers may be exposed to different health and safety risks in their occupation. For example, police officers are at risk of assault and homicide; the dynamics of policing as an occupation creates opportunities for them to experience many psychosocial hazards such as stress, suicide, sexual harassment, and discrimination. It is important that research be completed on the health and safety issues of police officers in order to identify hazards and identify ways to reduce risk. The failure to identify and solve health and safety concerns of officers has potentially serious consequences for the health and well being of officers and their families. These consequences can include depression, divorce, suicide, and disease. Not addressing the health and safety issues associated with policing may also impact the general public. For example, if an officer is...
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...Statistics and Computing Series Editors: J. Chambers D. Hand W. H¨ rdle a Statistics and Computing Brusco/Stahl: Branch and Bound Applications in Combinatorial Data Analysis Chambers: Software for Data Analysis: Programming with R Dalgaard: Introductory Statistics with R, 2nd ed. Gentle: Elements of Computational Statistics Gentle: Numerical Linear Algebra for Applications in Statistics Gentle: Random Number Generation and Monte Carlo Methods, 2nd ed. H¨ rdle/Klinke/Turlach: XploRe: An Interactive Statistical a Computing Environment H¨ rmann/Leydold/Derflinger: Automatic Nonuniform Random o Variate Generation Krause/Olson: The Basics of S-PLUS, 4th ed. Lange: Numerical Analysis for Statisticians Lemmon/Schafer: Developing Statistical Software in Fortran 95 Loader: Local Regression and Likelihood Marasinghe/Kennedy: SAS for Data Analysis: Intermediate Statistical Methods ´ Ruanaidh/Fitzgerald: Numerical Bayesian Methods Applied to O Signal Processing Pannatier: VARIOWIN: Software for Spatial Data Analysis in 2D Pinheiro/Bates: Mixed-Effects Models in S and S-PLUS Unwin/Theus/Hofmann: Graphics of Large Datasets: Visualizing a Million Venables/Ripley: Modern Applied Statistics with S, 4th ed. Venables/Ripley: S Programming Wilkinson: The Grammar of Graphics, 2nd ed. Peter Dalgaard Introductory Statistics with R Second Edition 123 Peter Dalgaard Department of Biostatistics University of Copenhagen Denmark p.dalgaard@biostat.ku.dk ISSN: 1431-8784 ISBN: 978-0-387-79053-4 DOI:...
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