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The Varicella-Zoster Virus: A Case Study

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The varicella-zoster virus (VZV), a DNA virus that causes chickenpox, is one of eight herpesviruses that can infect humans (Arvin 2008). Chickenpox is a contagious disease with symptoms of itchy red rashes (which can lead to skin infections) fatigue, and a fever (Centers for Disease Control and Prevention 2011). VZV causes chickenpox by entering into the respiratory tract and multiplying in the lungs and in regional lymph nodes. After the primary infection of the chickenpox, the virus goes dormant in the nerves and then the immune system stops responding to it. However, VZV can reactivate to cause herpes zoster to appear many years later (also known as shingles which has similar but mild symptoms to chickenpox) (Nagel and Gilden 2007). The immune system responses to the primary varicella-zoster virus by, first, using the innate immune system with the release antiviral cytokines and activation of the NK cells (Arvin 2008). In response, the NK cells release IFN-γ (a pro-inflammatory cytokines), which …show more content…
In real life, before the creation of the chicken pox vaccine, about 10,600 people were hospitalized with approximately 100 individuals died each due to chickenpox, which shows the problem that chickenpox can have on society without a proper vaccine (Centers for Disease Control and Prevention 2015). This amount is already contracted chickenpox I would use the herd immunity approach (which is immunizing non–immune individuals to prevent it from spreading) and prescribe non-aspirin medications, such as acetaminophen, to relieve fever from chickenpox and anti-itch cream. If this person were an adolescent or an adult with chickenpox, I would advise close surveillance and antiviral medication (such as Acyclovir) because they are more likely to have serious complications, such as pneumonia, than children are (Feder

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