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Urolithiasis

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Urolithiasis: Renal Stones
DEFINITION
* Nephrolithiasis refers to renal stone disease; urolithiasis refers to the presence of stones in the urinary system. Stones, or calculi, are formed in the urinary tract from the kidney to bladder by the crystallization of substances excreted in the urine
1. Urinary calculi are stones in urinary tract * a. Nephrolithiasis: stones form in kidneys * b. Urolithiasis: stones form in urinary tract outside kidneys
2. Highest incidence in * 3. Males more often affected than females (4:1) * 4. Most common in young and middle adults
B. Risk factors * 1. Majority of stones are idiopathic (no demonstrable cause) * 2. Prior personal or family history of urinary calculi * 3. Dehydration: increased urine concentration * 4. Immobility * 5. Excess dietary intake of calcium, oxalate, protein * 6. Gout, hyperparathyroidism, urinary stasis, repeated UTI infection
ETIOLOGY
* METABOLIC * LIFESTYLE * GENETIC FACTORS * DRUGS * OTHERS
RISK FACTORS * IMMOBILITY * SEDENTARY LIFE STYLE * DEHYDRATION * METABOLIC DISTURBANCES * HISTORY OF RENAL CALCULI
RISK FACTORS * HIGH MINERAL CONTENT IN DRINKING WATER * DIETARY INTAKE * UTI & H/O FEMALE GENITAL MUTILATION * PROLONGED INDWELLING CATHETERISATION * NEUROGENIC BLADDER
Development and location of calculi within the urinary tract

Pathophysiology
1. Factors leading to lithiasis include supersaturation (high concentration of insoluble salt in urine), pH of urine
2. Types of calculi
a. Calcium stones (calcium oxalate, calcium phosphate) * 1. Associated with high concentrations of calcium in blood or urine * 2. Genetic link
b. Uric acid stones * 1. Associated with high concentration of uric acid in urine * 2. Genetic link * 3. More common in males * 4. Associated with gout
c. Sturvite stones * 1. Associated with UTI caused by bacteria Proteus * 2. Stones are very large * 3. Staghorn stones in renal pelvis and calyces
d. Cystine stones: Associated with genetic defect
PATHOPHYSIOLOGY
* Slow urine flow, resulting in supersaturation of the urine with the particular element that first become crystallized and later become stone * Damage to the lining of the urinary tract * Decreased inhibitor substances in the urine that would otherwise prevent supersaturation and crystalline aggregation
TYPES OF STONES * Calcium Phosphate * Calcium oxalate * Uric acid * Cystine * Struvite
Manifestations
depends upon size and location of stones
1. Calculi affecting kidney calices, pelvis * a. Few symptoms unless obstructed flow * b. Dull, aching flank pain
2. Calculi affecting bladder * a. Few symptoms * b. Dull suprapubic pain with exercise or post voiding * c. Possibly gross hematuria
3. Calculi affecting ureter, causing ureteral spasm * a. Renal colic: acute, severe flank pain of affected side, radiates to suprapubic region, groin, and external genitals * b. Nausea, vomiting, pallor, cool, clammy skin * 4. Manifestations of UTI may occur with urinary calculi
COMPLICATION
1. Obstruction: manifestations depend upon speed of obstruction development; can ultimately lead to renal failure
2. Hydronephrosis:distention of renal pelvis and calyces; unrelieved pressure can damage kidney (collecting tubules, proximal tubules, glomeruli) leading to gradual loss of renal function * a. Acute: colicky pain on affected side * b. Chronic: few manifestations: dull ache in back or flank * c. Other manifestations: hematuria, signs of UTI, GI symptoms
Management
Collaborative Care * 1. Relief of acute symptoms * 2. Remove or destroy stone * 3. Prevent future stone formation
Diagnostic Tests * 1. Urinalysis: hematuria, possible WBCs and crystal fragments, urine pH helpful to diagnose stone type * 2. Chemical analysis of stone: All urine must be strained and saved; stones or sediment sent for analysis * 3. 24-urine collection for calcium, uric acid, oxalate to identifiy possible cause of lithiasis * 4. Serum calcium, phosphorus, uric acid: identify factors in calculi formation * 5. KUB xray (kidney, ureters, bladder): flat plate to identify presence and location of opacities * 6. Renal ultrasonography: sound waves to detect stones and detect hydronephrosis * 7. CT scan of kidney: identify calculi, obstruction, disorders * 8. IVP * 9. Cystoscopy: visualize and possibly remove calculi from urinary bladder and distal ureters * Medications * 1. Treatment of acute renal colic: analgesia and hydration * 2. Narcotic such as intravenous morphine sulfate, NSAID, large amounts of fluid by oral or intravenous routes * 3. Medications to inhibit further lithiasis according to analysis of stone: * a. Thiazide diuretics: promotes reduction of urinary calcium excretion * b. Potassium citrate: used to alkalinize urine for stones formed in acidic urine (uric acid, cystine, and some calcium stones) * Dietary Management: Prescribed to change character of urine and prevent further lithiasis
1. Increased fluid intake to 2 – 2.5 liters daily, spaced throughout day
2. Limited intake of calcium and Vitamin D sources if calcium stones
3. Phosphorus and/or oxalate may be limited with calcium stones
4. Low purine (rich meats) diet for clients with uric acid stones

DIAGNOSTIC STUDIES * RETROGRADE PYELOGRAM * CT SCAN * 24 HOUR URINE SPECIMEN * LAB INVESTIGATIONS
Surgery
1. May be indicated as treatment depending on stone location, severe obstruction, infection, serious bleeding
2. Types: * a. Ureterolithotomy: incision into affected ureter to remove calculus * b. Pyelolithotomy: incision into and removal of stone from kidney pelvis * c. Nephrolithotomy: surgery to remove staghorn calculus in calices and renal parenchyma * d. Cystoscopy: crushing and removal of bladder stones through cystocope; stone fragments irrigated out of bladder with acid solution
Nursing Care * 1. Focus on comfort during renal colic, diagnostic procedures, ensure adequate urine output, prevent future stone formation * 2. Health promotion: adequate fluid intake for all clients, adequate weight-bearing activity to prevent bone resorption, hypercalcuria, prevention of UTI
Nursing Diagnoses * 1. Acute Pain * a. Adequate pain management * b. Intensity of pain can cause vaso-vagal response; client may experience hypotension, syncope; client safety must be maintained
Impaired Urinary Elimination * a. Teaching client and strain all urine; send recovered stones for analysis * b. Complete obstruction causes hydronephrosis on involved side; other kidney continues forming urine; monitor BUN, Creatinine * c. Maintain patency and integrity of all catheters; all catheters need to be labeled, secured, and sterility maintained * 3. Deficient Knowledge: Client participation in treatment and prevention

Home Care * 1. Education regarding management current treatment and prevention * 2. Clients may be discharged with catheters, tubes, dressings; home care referral
PREVENTION
* Avoid protein intake; usually protein is restricted to 60g/day to decrease urinary excretion of calcium and uric acid. * A sodium intake of 3 to 4 g/day is reLow-calcium diets are not generally recommended,except for true absorptive hypercalciuria. Evidence shows that limiting calcium, especially in women, can lead to osteoporosis and does not prevent renal stones. * Avoid intake of oxalate-containing foods (eg, spinach,strawberries, rhubarb, tea, peanuts, wheat bran). * commended. Table salt and high-sodium foods should be reduced, because sodium competes with calcium for reabsorption in the kidneys. * During the day, drink fluids (ideally water) every1 to 2 hours. * Drink two glasses of water at bedtime and an additional glass at each nighttime awakening to prevent urine from becoming too concentrated during the night. * Avoid activities leading to sudden increases in environmental temperatures that may cause excessive sweating and dehydration. * Contact your primary health care provider at the first sign of a urinary tract infection

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