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Bipolar I Disorder Analysis

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Bipolar disorder (BD) is a chronic psychiatric disorder that associated with severe changes in the mood. One type of this disorder is Bipolar I Disorder or used to be referred as Bipolar Affective Disorder, which is characterized by periods of deep, prolonged and profound depression that alternate with periods of excessively elevated mood known as Mania. Although, Major depression episodes are common in Bipolar I Disorder, according to DSM-5, it is not required for the diagnosis of Bipolar I Disorder (American Psychological Association, 2013).
The primary key feature for diagnosing the patient with Bipolar I Disorder is the manic episode as at least one lifetime manic episode is required for the diagnosis of Bipolar I Disorder. DSM-5 criteria …show more content…
The main difference between both disorders is either the presence of manic or hypomanic episode to diagnose the patient with either Bipolar I or II disorders respectively. Although, in the hypomanic episode, the patient should show symptoms like manic episode, but such symptoms would last for 4 consecutive days not a whole week like manic episodes. At the same time, hypomanic episodes are not severe enough to cause marked impairment in the patient’s social or occupational life to necessitate hospitalizations. Also, hypomanic episode does not have psychotic features as the presence of a psychotic feature would diagnose the patient with manic episode not hypomanic one (American Psychological Association, …show more content…
Equally well, the alternation in the dopaminergic system, decreased expression and polymorphism on brain derived neurotrophic factors, the alternation in c-AMP responsive element binding, and dysregulation of calcium channel signaling are associated with the presence of Bipolar Disorder (Andreazza et al., 2014).
Furthermore, studies have been done on the genetics of Bipolar Disorder discovered that there are many loci are known to be involved in the development of Bipolar Disorder. These loci are about 12 in numbers, are grouped as major affective disorder (MAFD) loci and even they are numbers according to the time of their discoveries. One of these loci is MAFD 8 which is located at 10q21 and it is linked to the expression of the ANK3 gene.
The analysis of Genome – wide association studies (GAWSs) data indicated that both ANK3 and CACNA1C (alpha 1C subunit of the L-type voltage- gated calcium channel) represent the inherited basis for Bipolar Disorder. Even more, with a larger GAWS study of psychiatric disorder been published by the Cross -Disorder Group of the Psychiatric Genomic Consortium that there is a single – nucleotide polymorphism (SNPs) is associated with the range of childhood or adulthood psychiatric disorder (Rueckert et al.,

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