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Cowpox Infection Case Study

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Although human cowpox virus infection is in general characterized by mild and self-limiting lesions, cowpox may also lead to fatal outcome, especially in immune-compromised individuals including those suffering from atopic skin diseases (110, 141). The normal course of infection in humans was reconstructed by Baxby et al in an overview of 54 cases (140). It was shown, that in contrast to smallpox, CPXV infection in humans is spread through direct inoculation of CPXV into skin and/or oral mucous membranes by the use of small lesions. In consequence of the inoculation, the distinctive skin lesions develop. Next, inflamed macules occur that change to papulo-nodular or vesicular, then sterile pustules; later central hemorrhagic necrosis covered by a black eschar and often surrounded by erythema and indurated edema is formed (140). Cases of conjunctivitis and keratitis have also been registered. Nonetheless, fatal disease occurs seldom and is not completely characterized, even though isolated cases of encephalitis and heart failure have been reported (141). Furthermore, autoinoculation potentially contributes to the development of additional cutaneous and/or mucosal lesions.
Lately increasing number of human CPXV infections, obtained through the contact with infected pet rats are recorded (123, 127, 150). In these cases, the animals …show more content…
Rat, 6 days after intranasal cowpox virus (CPXV) infection. Picture 2 Singular pox lesion at the dorsal view of the hind limb. Picture 3. Skin, tail. Rat, 23 days after intradermal CPXV infection. Reddening, swelling, and necrosis of the scarified skin. Picture 4. Skin, lips, and tongue. Rat, 11 days after intradermal CPXV infection. Swelling of the lips and tongue with superficial necrosis. Picture 5. Hind foot. Rat, 23 days after intradermal CPXV infection. Necrosis of the distal phalanx. Reprinted by permission from SAGE Publications: (Veterinary Pathology) (158), copyright

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