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Pseudomonas Aeruginosa Case Study

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Background
Pseudomonas aeruginosa is an important cause of hospital acquired infection. It is frequently recovered species from clinical specimens and multidrug resistant P. aeruginosa are increasingly being reported worldwide. The important factor responsible for aminoglycoside resistance is Aminoglycoside modifying enzymes (AMEs), carried by mobile genetic elements. In spite of high resistance, aminoglycosides are still an important treatment option in infection with P. aeruginosa.
Aim: The study was conducted to determine the prevalence of plasmid mediated Aminoglycoside modifying enzymes coding genes in Pseudomonas aeruginosa.
Methods: One hundred and forty consecutive, non-repeat isolates of Pseudomonas aeruginosa were collected from various clinical samples and analyzed for antibiotic profile. Amikacin – ceftazidime and gentamicin – ceftazidime combinations were used
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It is one of the important public health problems around the world. In association with increased morbidity and mortality, HAI are important cause of prolonged hospital stay, inconvenience to the patients and an economic burden on health care. [1] Decreased immunity, increasing numbers of invasive techniques, critical life saving operations and immunosuppressive therapies are frequently associated with transmission of drug-resistant bacteria among patients in hospitals with poor infection control practice. Though limited data on HAIs are available from developing countries, HAIs are most common in Intensive care units (ICU), acute surgical and orthopaedic wards. The most frequent HAIs are infections of the surgical wounds, urinary tract infections. Blood stream infection and infections of lower respiratory tract including ventilator associated pneumonia are also very frequent in hospitalized patients. However, bloodstream infections and lower respiratory tract infections are the most lethal.

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