Free Essay

Quality Manage Case

In:

Submitted By richdynamite
Words 279
Pages 2
Abstract
Toxoplasma gondii, an obligate intracellular pathogen, has a strong affinity for nervous system. TgCtwh3, a representative ChineseⅠToxoplasma strain prevalent in China, has both characters of Type I and Type II Toxoplasma. The interaction of this atypical strain with host cells still remains elusive by far. Using a transwell system, neural stem cells C17.2 were co-cultured with the tachyzoites of TgCtwh3 or standard Type I RHstrain, the apoptosis levels of C17.2 cells and the expression levels of related proteins in the ERS-mediated pathway were detected by flow cytometery and western blotting. Results show that the apoptosis levels of C17.2 cells co-cultured with TgCtwh3 had significant increases versus the negative control group; however, the apoptosis level in the TgCtwh3 group were significantly lower than the RH co-culture group. Western blotting analyses reveal that after co-cultured with TgCtwh3 and RH tachyzoites, the expression levels of caspase-12, CHOP and p-JNK in C17.2 cells increased significantly when compared with control groups. After the pretreatment of Z-ATAD-FMK, an inhibitor of caspase-12, the apoptosis level of C17.2 co-cultured with TgCtwh3 or RH tachyzoites had an apparent decline, and the expression levels of those related proteins were significantly decreased. Our finding suggests that TgCtwh3 can induce the apoptosis of C17.2 by the up-regulation of caspase-12, CHOP and p-JNK, which are associated with endoplasmic reticulum stress signaling pathways. This work contributes to better understanding of the possible mechanism of brain pathological damage induced by T. gondii prevalent in China, and also reveals the potential value of ERS inhibitor to treat such related diseases in the future.

Similar Documents

Premium Essay

Resume

...PLacerra@gmail.com     Senior Quality Assurance professional expert in the design and delivery of cost-effective, high-performance technology in support of growth with budget responsibilities up to all phases of Quality Assurance, the project life cycle, from initial feasibility analysis and conceptual design through implementation and enhancement.  Effective at building culturally diverse, team-centered operating units, with excellent business process and strategy development skills.  Expert at planning, managing and executing all life cycle activities such as test strategy, defect tracking, testing estimation and test planning.  |   |   |   | SUMMARY OF QUALIFICATIONS   Knowledge & Expertise - 25 plus years of expertise in Software Testing/Quality Assurance Management, Risk Management, Data Warehousing, Defect Management and Resource Management. Process improvement and optimization focus - Improve software quality, meet customer expectations and reduce defects by supporting proven software quality practices as well as implementing practical and effective process improvement methods.   Flexible - Demonstrated ability to excel in process oriented organizations requiring strict adherence to regulations as well as those requiring out of box thinking for new and effective process implementation and adherence.   Self motivated fast learner - Constant focus on enhancing knowledge / expertise by keeping pace with latest developments in software quality, testing and management...

Words: 1785 - Pages: 8

Premium Essay

Top Ten Pm Skills

...start and end dates. Other characteristics of a project include a defined scope, finite budget, specific end results (or deliverables), and assigned resources. Another characteristic of a project is that the work is unique. Even if one project is similar to another, it’s not exactly the same because circumstances change and things are always different when you’re dealing with people. One of the primary roles of managers is to manage the work process. While small projects don’t necessarily require much knowledge of project management or much project management discipline, as a project gets larger, there is more need to utilize formal processes and techniques. Different project management methodologies organize and structure these processes in various ways. The goal for this project management primer is to examine 10 basic skills of project management: 1. Define the project 2. Plan the work 3. Manage the workplan 4. Manage issues 5. Manage scope 6. Manage risks 7. Manage communication 8. Manage documentation 9. Manage quality 10. Manage metrics In general, if you can master these areas, you can succeed in most projects. Project work vs. project management Notice that the list doesn’t include analysis, design, testing, or implementation. Those who have worked on projects probably know that they typically include analysis and testing. However, there is a major distinction to be made. Analysis and testing are part of the actual project work effort (also called...

Words: 5340 - Pages: 22

Premium Essay

Case Study

...Leadership I. Case Background : Mr. Hing Lim owner and president of the (HTC) HING TYRE COMPANY . Since 1990 when the business was started more client are interesting about their production because of their ability to repair and re-arrange a car into a standard quality. Mr. Hing also give a discount of 8% and warranty atleast 2 years for those people who willing to repair their car. Months later they grew rapidly and they promote their work and the feedback of the costumer was good and better. In that case Mr. Hing gave a high salary per employee. Year has past the company can achieve their goal. It was year (2011) when Mr. Hing died. He has one successor Mr. Wuang Lim who manage now the company. He was too young to manage the company until now. However the company was faced with a serious problem. Because of lack of information regarding their position taken. They buy a shoddy substandard product. They also renew the discount instead of 8% he made it 5% then the 2 year warranty he made it 1 year warranty. He also decreased the salary of every employee he made it into regular and exact salary. But the big and scary problem, mostly of substandard product prevent a failure work and easily ruin. In that case mostly of their costumer have been transfer to another company and the other employee getting resigned because of wrong handling of the company. And now there company turning in bankruptcy. How...

Words: 833 - Pages: 4

Premium Essay

Work

...RESOURCES | 12 | 1 WELCOME AND INTRODUCTION The overall function and direction of an organisation is determined by the nature of its corporate strategy. Strategy provides the goals, objectives and guidelines for the structure and operations of the organisation. It is by means of structure that the purpose and work of the organisation are carried out. Some structure is necessary to make possible the effective performance of key activities and to support the efforts of staff. Structure provides the framework of an organisation and its pattern of management. The manager needs to understand the importance and effects of organisation strategy and structure. The aim of this unit is to provide learners with the understanding and skills to manage their | activities in the business workplace to improve their effectiveness and efficiency. | This unit focuses on the effective and efficient planning and management of business work | activities. It gives learners with understanding and skills needed to design and implement | operational systems to improve their effectiveness and efficiency and achieve the desired results for the business. | | You are encouraged to consider the importance and interrelationship of business processes and the implementation of operational plans, together...

Words: 3446 - Pages: 14

Premium Essay

Business Plan

...All instructional text is displayed in blue font colour in the template. These should be deleted prior to the document being distributed for review and approval. Update text within square brackets which is placeholder text with relevant text. E.g. [yyyymmdd] should be changed to latest date 20130305 Use this basic structure and type sizing for all your covers. Do not manipulate or rescale any of the graphic components. Use initial caps in your headings with capital letters for proper nouns only. Document Control Document location Location | | Author Position | Name | Contact no | | | | Stakeholders and other contributors Consider key stakeholders who might have input in the decision to approve or reject the Business Case. Typically, distribution to the relevant governance forum members’ is required for a one-on-one walkthrough prior to presenting. The costs section of the document may need to be removed from widely distributed versions. Position | Name | | | | | Revision history Version | Issue date | Author/editor | Description/Summary of changes | | | | | | | | | Reviewed by Version | Issue date | Name | Position | Review date | | | | | | | | | | | | | | | | Approvals Approval refers to the approver’s acceptance of the content and overall intention of this document, including acceptance of any commitments described in order to successfully deliver the initiative. The approver, where relevant, also confirms...

Words: 2808 - Pages: 12

Premium Essay

Manager

...RAJEEV KUMAR Professional Summary: • Highly talented and accomplished Information Technology professional with extensive background in QA engineering, Project Management and Scrum Master. • Improve software quality, meet customer expectations and reduce defects by supporting proven software quality practices and implementing practical and effective process improvement methods. • Plan and perform effective software testing through a combination of familiar structured test techniques, rapid test practices and test automation where applicable. Experience Summary: ✓ Sound Experience in Full Software Testing Life Cycle (Involvement in Test Strategy, Test cases, Test Scripts/Data, Defect tracking/prevention) and its most of phases e.g. Unit Testing, Functional Testing, Regression Testing, Integration Testing, System Testing and User Acceptance Testing, Ajax Testing. ✓ Adherence to software development life cycle, quality methodologies (ISO 9001/CMM) and best practices of software testing models (Agile Methodology). ✓ Expert in both Manual testing and Automated testing Using tools Selenium - Java. ✓ Experience in Functional & GUI testing in CRM and ERP domain. ✓ Experience in Database Testing (MySql). ✓ Successfully Participated in 32 hrs training on automation tools such as Mercury Interactive Quick Test Pro 9.2, Test Director (QC). ✓ Solid communicator with exceptional team-building skills. ✓ Strong problem-solver...

Words: 1430 - Pages: 6

Premium Essay

Social Capital

...range from simple consultation with suppliers on design ideas to making suppliers fully responsible for the design of components or systems they will supply. In this paper, we develop and test a conceptual model of the effect of elements of the supplier integration process on cost, quality, and new product development time, under conditions of technology uncertainty. Technology uncertainty is operationalized here, as the degree to which the product or process technologies employed in the project are new, complex, and/or rapidly changing. The results suggest that technology uncertainty have a negative impact on cost results, but no direct effect on quality or cycle time. The results also show that certain elements of the supplier integration process are more likely to be employed under conditions of technology uncertainty, leading to significant improvements in cost, quality, and cycle time objectives. D 2001 Elsevier Science Inc. All rights reserved. Keywords: Product development; Suppliers; Collaboration; Purchasing; Technology; Structural equation modeling 1. Introduction Firms in many industries face increasing global competition and markets that demand more frequent innovation and higher quality. These firms are looking for...

Words: 8677 - Pages: 35

Free Essay

Learning from the Titanic

...Suranthe de Silva Overview • Snapshot • Understand what went wrong • Blame-game and performance evaluation • Factors during voyage • Learning from History • How it relates to the IT field Snapshot of circumstance... • Business case • • • • Safety and Luxury through new technology Unparalled Customer Experience 6 year construction and 2 year breakeven. 75% of revenue from first class – reflects in space allocation: 60% for 905 first-class and 7% for 1134 third-class Lavish attention and money substituted processes Marketing drive: ‘unsinkable ship’ Traditional safety (life-boats) given low priority Project Manager (Captain Smith) didn’t trust new methodologies (ice bucket test) • Implied non-functional requirements due to perception/assumptions • • • • • Over-confidence • Old School • Political Influence • • Project Sponsor (Bruce Ismay) High Expectations set – arrive a day early Snapshot of what happened... • Business and Economic pressures • • • • • • • Under-prepared (lack of equipment) and untrained crew – 83 of 900 were mariners Under-quality material substituted Untested processes/methods Traditional safety methods (life-boats) given low priority Safety: only mitigation by technology and no contingency/worst-case (life-boats) Testing: was maiden voyage Prove Titanic is the best ship even when grounded (Fatal) • Over-confidence • Decisions based on aesthetics and luxury compromised individual safety features • • • • • • 16 vs 48 lifeboats...

Words: 903 - Pages: 4

Premium Essay

Orion Project Shield Case

...Individual Team Assignment Case Analysis of the Orion Shield Project Dennis J Paffrath April 18, 2013 AMBA 640 Professor Marsh 1 Table of Content Executive Summary…………………………………………………………….3 Technical Issues…………………………………………………………………5 Initiating Process Group…………………………………………………5 Planning Process Group…………………………………………………5 Executing Process Group………………………………………………..10 Monitoring and Controlling Process Group…………………………….11 Closing Process Group………………………………………………….14 Ethical Issues……………………………………………………………………15 Legal and Contractual…………………………………………………………..16 Conclusion………………………………………………………………………17 References………………………………………………………………………18 2 Executive Summary K. Schwalbe (2012) has provided a basic understanding of what project management is and explains that it requires planning and use and management of organizational resources in order to complete a project within the required time, scope and cost. Project managers must understand that one of the most important aspects of project management is to complete a project with a successful delivery of the product while ensuring that it is within the required timeline and within the resources allocated to the project. Therefore, it is imperative that the managing of a project makes efficient use of time, resources, cost, risk, quality and scope. By understanding these constraints, the project manager will be able to successfully complete the project. In reviewing the Orion Shield project case, it is very clear that the Scientific...

Words: 4699 - Pages: 19

Premium Essay

Title

...Experience Summary: * About 5 years of experience in IT industry as a Software Quality Analyst. * Proficient in manual testing of web based technologies. * Solid Experience in Agile Methodology process. * Strong Expertise in Sanity, Functional, System and Regression Testing. * Very strong in Requirements understanding and analyzing. * Solid Experience in preparation of Test scenarios, Test cases and executing the same. * Very good in test results analyzing and bug reporting. * Familiar with SDLC, STLC and Bug Life Cycle. * Solid domain knowledge in Banking, Insurance. * Strong expertise in using of SQL, in order to check the data validity and data integrity. * Prepared Daily & Weekly test status reports. * Strong Experience in using Quality Center. * Quick learner and excellent team player having ability to meet tight deadlines and work under pressure. Would create more value for the company and for the customer. * Flexible and versatile to adapt to any new environment and work on any project. * Great communication skills. * Confident and resourceful with a willingness to learn new concepts and apply them to yield successful results. * Expertise in Pega Application Testing. Educational Qualification: * MCA from Osmania University in 2008 with aggregate 65%. WORK EXPERIENCE: Working as Software Quality Analyst in Virtusa Consulting Services, Hyderabad from Sep 2010 to Till Date. ...

Words: 857 - Pages: 4

Premium Essay

Sainsbury Case

...Case 2: A report on the case of Intermountain Health Care Introduction: This report analyses the case of Intermountain Health Care (IHC) which presents the idea of integrated model of health care system and provides perfect explanation of medical organization. The purpose of this report is to outline various lessons learned from the case of IHC and set an example for other medical organization by explaining success criteria of this case. Success criteria of the IHC: IHC has succeeded to deliver uniform quality medical care with continuous enhancement by implementing strategic vision in the organization and co-ordination among staff. For the health care organizations patient’s satisfaction is the essential key to success, by knowing this fact and to gain the satisfactory level of the patients, Intermountain has analysed and implemented qualitative principles for the satisfaction of patients. Also, with the help of these principles, Intermountain has planned the system. In this process of transformation at IHC, Dr. Brent James, a biostatistician and a surgeon, has played very important role and addressed the basic issues of quality management with the help of integration system. Simultaneously, as a result of integration system and as a part of organisational structure, Intermountain has found Dr W. Edwards Deming within the medical practice by mounting the cure percentage of patients which has made Intermountain unique from other health care organizations. To manage the delivery...

Words: 706 - Pages: 3

Premium Essay

Om 16

...objectives at the Penang Mutiara case study describing the team thoughts of how the hotel's management will: make sure that the way it manages the hotel is appropriate to the way it competes for business, and implement any change in the strategy and develop its operation so that it derives the long- term strategy of the hotel. In addition, the report addresses how the performance objectives might have internal benefits; and a concept from OM chapters was applied in the case. The report found that the way the management manages the hotel is appropriate to the way it competes for business. It shows that in order to implement any change in the current strategy, the hotels' management can make alliances or commercial agreements with other business, develop automatic system to offer services and payments and establish a database and provide membership with loyal customers being offered more free services or better prices or awards. The report also shows that adopting the performance objectives are very beneficial to Penang Mutiara. I. Introduction Though there are many luxurious hotels in the South- East region, the Penang Mutiara is considered one of the leading hotels in that region. This is because of a number of factors, including its differentiated strategy, good management, motivated employees and stylish design that support the luxury atmosphere. The aim of this report is to discuss how the hotel's management will: make sure that the way it manages the hotel is appropriate to...

Words: 2914 - Pages: 12

Premium Essay

Marketing Map

...Effective Solution Processes Effective Cost Management MARKET SEGMENTATION MODEL Learning & Growth Perspective Relationship Management Skills Solution Management Skills Operational Management Skills Successful Career Planning Accountability Industry Expertise Knowledge Management Entrepreneurial/Innovative Leverage Solutions Identify, Attract, & Retain Skilled Employees  2 ©2010 Palladium Group, Inc. Healthcare Strategy Map “Maximize the Quality of Life and Dignity of Older Adults” Increase Shareholder Value Financial Create Cash Flow Grow Revenue Create EBITDAR Manage Expenses Customer Trust Choice Consistency Pay For Service “Customer Satisfaction Through...” Business Process “…Quality Service” Excel at Quality Resident Healthcare “Operational Efficiency” Optimize Rate and Occupancy Management Leverage the Right Assets Aggressively Manage Residence Expenses Manage Media Exposure “…Quality Relationships” Develop Customer Trust Proactively Manage Litigations & Regulations Excel at Other Resident Services...

Words: 1122 - Pages: 5

Premium Essay

Lvmh

...Case 3-4: LVMH: Managing the Multi-Brand Conglomerate 1. LVMH’s diversification represents the group’s strong presence in the luxury goods market as a whole with products from the fashion and leather range, wines and spirits range, watches and jewelry range, perfumes and cosmetics range, and finally the selective retailing range. This strategy aims to claim market share in market segments that are interrelated with the specific customer segment as the common denominator. LVMH is a market leader in some markets and has a decent market share in others and aims to be the leader in the luxury market as a whole where the elite customers can recognize its brands from all of its product ranges and the company plans to build brand loyalty within those customers so that a customer who chooses LVMH for watches for instance, is also inclined to choose an LVMH product for wine and spirits. Diversification also spreads the company’s costs over a number of brands and the revenues as well so that it can always insure good rate of return for investors. 2. For a company like LVMH to compete on a scope that includes champagne, jewelry, fashion, cosmetics, and retailing is logical and even necessary for it to keep a competitive edge because its competitors have implemented the same strategy to fight for market share in the luxury market in all of its segments. The company’s policy aims to build the idea in their customers’ heads that they can always expect the same consistent high-end...

Words: 1843 - Pages: 8

Premium Essay

Case Study

...Effective Solution Processes Effective Cost Management MARKET SEGMENTATION MODEL Learning & Growth Perspective Relationship Management Skills Solution Management Skills Operational Management Skills Successful Career Planning Accountability Industry Expertise Knowledge Management Entrepreneurial/Innovative Leverage Solutions Identify, Attract, & Retain Skilled Employees  2 ©2010 Palladium Group, Inc. Healthcare Strategy Map “Maximize the Quality of Life and Dignity of Older Adults” Increase Shareholder Value Financial Create Cash Flow Grow Revenue Create EBITDAR Manage Expenses Customer Trust Choice Consistency Pay For Service “Customer Satisfaction Through...” Business Process “…Quality Service” Excel at Quality Resident Healthcare “Operational Efficiency” Optimize Rate and Occupancy Management Leverage the Right Assets Aggressively Manage Residence Expenses Manage Media Exposure “…Quality Relationships” Develop Customer Trust Proactively Manage Litigations & Regulations Excel at Other Resident Services...

Words: 1122 - Pages: 5