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Breast Cancer Critique

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Triple negative breast cancer (TNBC) is a type of breast cancer that when tested for estrogen receptors (ER-), progesterone receptors (PR-), and HER2 (HER2-) they all come negative. The results that came out negative for all three means the cancer is triple-negative. However, these negative results mean that the growth of the cancer is not sustained by the estrogen, progesterone hormones, and the HER2 receptors. Therefore, triple-negative breast cancer (TNBC) cannot be treated with hormonal therapies such as tamoxifen and aromatase inhibitors. Also, it cannot be treated with therapies that target HER2 receptors, such as Herceptin. Scientists now are testing other medicines such as Tat-SID, which can be used to treat triple-negative breast cancer. To understand triple-negative breast cancer, it’s important to understand the receptors, which are proteins that are found inside and on the surface of cancerous cell. These receptor proteins are the senses of the cell, they receive messages/signals from substances in the bloodstream and the cell respond to these signals.
In this research, the mouse metastatic mammary 4T1 tumor cell line was used as well as human breast adenocarcinoma cell line, mouse mammary tumor MMTV-Myc cell line, RPMI supplemented with fetal bovine serum, …show more content…
This results or findings opens new door of medicine to treating TNBC, which as stated previously cannot be treated with hormonal therapies or therapies that target HER2 receptors. In the article, scientists succeed to prove that Tat-SID effectively blocked the SIN3A-PF1 interaction in MDA-MB-231 cells (Article 29, page 2). In additional to blocking a decrease in the association between SIN3A and MRG15 following Tat-SID treatment was also

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