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Cellulose Lab Report

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2.6 OXIDIZED CELLULOSE:
Cellulose-based materials are available as oxidized regenerated cellulose obtained from wood pulp cellulose and oxidized cellulose obtained from cotton fiber. They are completely biodegradable, biocompatible, absorb up to 7 times their own weight. They are available in various forms like single or multiple sheets, mesh, gauze, sponges, and woven strips.

Fig 8: Cellulose structure [1]
Cellulose acts as a physical matrix to support clot formation. They do not contain any intrinsic coagulation components; but stimulate clot formation and provide a constructive three-dimensional structure for clot organization. In order to function, therefore, a functional coagulation system must be present. [3, 6, 15, 38, 43, 46, 48, 19, …show more content…
It is delivered using a dual chamber delivery system with each chamber consisting of fibrinogen and platelets from the patient’s centrifuged plasma. The clot is held together by the platelets and the growth factors and proteins in the gel promote tissue regeneration. It is used widely in orthopedic, hepatic, reconstructive, and general surgical procedures. It may have reduced strength when used in combination with methyl methacrylate or other acrylic adhesives. It is costly and successful use is dependent on operator experience. The need for centrifuge and peruse processing makes the product less smart. [24, 38, 49]
2.13 HEMOSTATIC AGENTS:
2.13.1 APROTININ:
Aprotinin is a serine proteinase inhibitor made up of 58-residue polypeptide chain.it exhibits its action by formation of reversible enzyme–inhibitor complexes with proteases such as plasmin, trypsin, kallikrein, chymotrypsin, activated protein C, and thrombin. The enzymatic activity of aprotinin is given in kallikrein inactivator units (KIU), with 1 KIU defined as the amount of aprotinin that decreases the activity of two biological kallikrein units by 50%. Aprotinin exert its hemostatic effects by inhibiting the flowing plasmin but does not react with fibrin-bound plasmin. [30, 32]
Aprotinin has been vastly used in cardiac surgery and has been described in other studies such as orthopedic surgery and hepatic transplantation. It has consistently been reported to reduce blood loss and transfusion

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