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Traditional Biotech

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* Calmette was a French physician, bacteriologist and immunologist, and an important officer of the Pasteur Institute.

* He discovered the Bacillus Calmette-Guérin (BCG), an attenuated form of Mycobacterium used in the BCG vaccine against tuberculosis.

* He also developed the first antivenom for snake venom, the Calmette's serum.

* In 1890, Calmette met Louis Pasteur who was his professor in a course on bacteriology. He became an associate and was charged by Pasteur to found and direct a branch of the Pasteur Institute at Saigon (now Ho Chi Minh), in 1891.

* Calmette was a French physician, bacteriologist and immunologist, and an important officer of the Pasteur Institute.

* He discovered the Bacillus Calmette-Guérin (BCG), an attenuated form of Mycobacterium used in the BCG vaccine against tuberculosis.

* He also developed the first antivenom for snake venom, the Calmette's serum.

* In 1890, Calmette met Louis Pasteur who was his professor in a course on bacteriology. He became an associate and was charged by Pasteur to found and direct a branch of the Pasteur Institute at Saigon (now Ho Chi Minh), in 1891.

Léon Charles Albert Calmette (July 12, 1863 – October 29, 1933)

Works * In the Pasture Institute, he dedicated himself to the nascent field of toxicology, and he studied snake and bee venom, plant poisons and curare. * He also organized the production of vaccines against smallpox and rabies and carried out research on cholera, and the fermentation of opium and rice. * He developed the first antivenins for snake bites using immune sera (Calmette's serum). * In 1892, Calmette thought of an idea that snake antivenin might be manufactured by injecting animals with increasing doses of heated venom.

* Horses and donkeys were injected with increasing doses of cobra venom until they could withstand some 200 time the fatal dose of active venom.

* After proving the efficacy of the experiment, the serum was preserved and on the latter antivenins for spider and scorpion bites were introduced.

* Calmette's main scientific work was the attempt to develop a vaccine against tuberculosis, which, at the time, was a giant killer disease. Finally, in 1921, they used BCG to successfully vaccine newborn infants in the Charité in Paris.

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