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Rheumatoid Arthritis Case Study

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According to the CDC, arthritis affects over 52 million American adults, with an estimated 67 million projected to have activity limitations by the year 2030 (CDC, 2015, para. 2). Arthritis the inflammation of one or more joints, resulting in symptoms that include stiffness and joint pain that often worsen with age. “Arthritis” is the general time for a musculoskeletal ailment, but there exist several types of arthritic conditions. Of these, rheumatoid arthritis (RA) is a common autoimmune form of the disease associated with progressive disability, systemic complications, early death, and socioeconomic costs (McInnes & Schett, 2011, p. 2205). The purpose of this discussion is to provide a disease process and management overview of rheumatoid …show more content…
This disease may begin at any time in life, as it is not the result of chronic cartilage degeneration, but instead it is an inflammatory disease where the body releases enzymes that attack its own healthy tissue. In RA, synovial inflammation, hyperplasia (“swelling”), autoantibody production, cartilage and bone destruction, and systemic features culminate to create a destructive condition. According to the NIH (2015), “enzymes destroy the lining of the joints, causing pain, swelling, stiffness, malformation, and reduced movement in function” (NIH, 2015, para. 5). Once the immune response is triggered, “cells of the immune system produce autoantibodies and inflammatory cytokines, creating a cascade of inflammation resulting in the formation of pannus, which invades and destroys cartilage and bone. Additional joint damage and systemic complications ensue” (Dewing et al., 2012, para. 8). Systemic complications can include cardiovascular, pulmonary, psychological, or skeletal disorders (McInnes & Schett, 2011, p. 2205). Often, RA affects small and large joints symmetrically on the body, such as hands, wrists, elbows, or balls of the feet (Guilan, 2013, p. 1857). Morning stiffness lasts for longer than an hour, and the disease is accompanied by other symptoms including fatigue and feeling ill, fever, weight loss, eye inflammation, anemia, subcutaneous nodules, or pleurisy (Guilan, 2013, p. …show more content…
Antirheumatic drugs, also known as disease-modifying antirheumatic drugs (DMARDs), collectively are prescribed to reduce symptoms. According to Wasserman (2011), “the choice of DMARD depends on a number of factors, including the stage and severity of the joint condition, the balance between possible side effects and expected benefits, and patient preference” (Wasserman, 2011, p. 1245). Glucocorticoids, non-steroidal anti-inflammatory medications (NSAIDs), antimetabolites, and antirheumatics may be prescribed to manage the symptoms. Glucocorticoids (cortisol, cortisone) decrease the body’s immune system response and aid in treating inflammation (Wasserman, 2011, p. 1245). Salicylates, such as aspirin, Acuprin, or ZORprin, are non-steroidal anti-inflammatories that inhibit the synthesis of prostaglandin, and have analgesic properties. Patients may also be prescribed an antimetabolite, such as methotrexate, which inhibits the growth of cells and decreases the activity of the immune system. DMARDs, such as hydroxychloroquine, are treated to slow the progression of the disease. Research by Wasserman (2011) found that gastroprotection should be used of patients are older than 65 years of age (Wasserman, 2011, p.

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